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Radiation-assisted metal ion interference tumor therapy by barium peroxide-based nanoparticles Electronic supplementary information (ESI) available. See DOI: 10.1039/c8mh01554f
Zhang, Meng; Shen, Bo; Song, Ruixue; Wang, Han; Lv, Bin; Meng, Xianfu; Liu, Yang; Liu, Yanyan; Zheng, Xiangpeng; Su, Weiwei; Zuo, Changjing; Bu, Wenbo
2019-06-01
Source PublicationMATERIALS HORIZONS
ISSN2051-6347
Volume6Issue:5Pages:1034
SubtypeArticle
AbstractIn high-Z element enhanced radiotherapy strategies, the clinical potential of metal-based nanocomposites is always reduced by the serious side effects of leaked heavy metal ions. In this study, we demonstrate a novel anticancer strategy to realize controllable cytotoxicity of metal elements with the aid of high-energy radiation, based on a design of chelator-modified barium peroxide nanoparticles (GL-BaO2 NPs). Free Ba2+ is a potassium channel inhibitor that inhibits cell proliferation. The chelator modification can strongly bind leaked free Ba2+, thus reducing its unwanted side effects in normal tissues. However, under X-ray radiation in tumor regions, the produced hydroxyl radicals will break the chemical structures of chelators. Consequently, the released Ba2+ can access the membrane without a barrier and contribute to tumor treatment. More importantly, the sensitization of Ba in the lattice of barium peroxide will directly transform peroxide groups into reactive hydroxyl radicals, which further guarantees the decomposition of chelators as well as the efficient killing of cells. This strategy, which we termed ion interference therapy, demonstrates a universal paradigm by employing the biological effects of metal ions in tumor treatment, revealing its industrial potential for radiotherapy enhancement.
DOI10.1039/c8mh01554f
Language英语
WOS Research AreaChemistry ; Materials Science
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27068
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Zhang, Meng,Shen, Bo,Song, Ruixue,et al. Radiation-assisted metal ion interference tumor therapy by barium peroxide-based nanoparticles Electronic supplementary information (ESI) available. See DOI: 10.1039/c8mh01554f[J]. MATERIALS HORIZONS,2019,6(5):1034.
APA Zhang, Meng.,Shen, Bo.,Song, Ruixue.,Wang, Han.,Lv, Bin.,...&Bu, Wenbo.(2019).Radiation-assisted metal ion interference tumor therapy by barium peroxide-based nanoparticles Electronic supplementary information (ESI) available. See DOI: 10.1039/c8mh01554f.MATERIALS HORIZONS,6(5),1034.
MLA Zhang, Meng,et al."Radiation-assisted metal ion interference tumor therapy by barium peroxide-based nanoparticles Electronic supplementary information (ESI) available. See DOI: 10.1039/c8mh01554f".MATERIALS HORIZONS 6.5(2019):1034.
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