KMS Shanghai Institute of Ceramics，Chinese Academy of Sciences
| Biodegradable Fe(III)@WS2-PVP Nanocapsules for Redox Reaction and TME-Enhanced Nanocatalytic, Photothermal, and Chemotherapy | |
| Wu, Chenyao; Wang, Shige; Zhao, Jiulong; Liu, Yiyun; Zheng, Yuting; Luo, Yu; Ye, Chongqing; Huang, Mingxian; Chen, Hangrong | |
| 2019-06-01 | |
| Source Publication | ADVANCED FUNCTIONAL MATERIALS
 |
| ISSN | 1616-301X |
| Volume | 29Issue:26 |
| Subtype | Article |
| Abstract | In this study, biocompatible Fe(III) species-WS2-polyvinylpyrrolidone (Fe(III) @ WS2-PVP) nanocapsules with enhanced biodegradability and doxorubicin (DOX) loading capacity are one-pot synthesized. In this nanocapsule, there exists a redox reaction between Fe(III) species and WS2 to form Fe2+ and WO42-. The formed Fe2+ could be oxidized to Fe3+, which reacts with Fe(III) @ WS2-PVP again to continuously produce Fe2+ and WO42-. Such a repeated endogenous redox reaction leads to an enhanced biodegradation and DOX release of DOX @ Fe(III) @ WS2-PVP. More strikingly, the Fe2+ generation and DOX release are further accelerated by the overexpressed H2O2 and the mild acidic tumor microenvironment (TME), since H2O2 and H+ can accelerate the oxidation of Fe2+. The continuously generated Fe2+ catalyzes a fast Fenton reaction with the innate H2O2 in tumor cells and produces abundant highly toxic hydroxyl radicals for nanocatalytic tumor therapy. Together with the high photothermal transforming capability, the DOX @ Fe(III) @WS2-PVP nanocapsules successfully achieve the endogenous redox reaction and exogenous TME-augmented tumor photothermal therapy, chemo and nanocatalytic therapy outcome. The concept of material design can be innovatively extended to the synthesis of biodegradable Fe(III) @ MoS2-PVP nanocomposite, thus paving a promising novel way for the rational design of intelligent theranostic agents for highly efficient treatment of cancer. |
| Keyword | biodegradable Fenton reaction nanocapsules trimodal tumor therapy |
| DOI | 10.1002/adfm.201901722 |
| Language | 英语 |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.sic.ac.cn/handle/331005/27067 |
| Collection | 中国科学院上海硅酸盐研究所 |
| Recommended Citation GB/T 7714 | Wu, Chenyao,Wang, Shige,Zhao, Jiulong,et al. Biodegradable Fe(III)@WS2-PVP Nanocapsules for Redox Reaction and TME-Enhanced Nanocatalytic, Photothermal, and Chemotherapy[J]. ADVANCED FUNCTIONAL MATERIALS,2019,29(26). |
| APA | Wu, Chenyao.,Wang, Shige.,Zhao, Jiulong.,Liu, Yiyun.,Zheng, Yuting.,...&Chen, Hangrong.(2019).Biodegradable Fe(III)@WS2-PVP Nanocapsules for Redox Reaction and TME-Enhanced Nanocatalytic, Photothermal, and Chemotherapy.ADVANCED FUNCTIONAL MATERIALS,29(26). |
| MLA | Wu, Chenyao,et al."Biodegradable Fe(III)@WS2-PVP Nanocapsules for Redox Reaction and TME-Enhanced Nanocatalytic, Photothermal, and Chemotherapy".ADVANCED FUNCTIONAL MATERIALS 29.26(2019). |
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