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Biodegradable Fe(III)@WS2-PVP Nanocapsules for Redox Reaction and TME-Enhanced Nanocatalytic, Photothermal, and Chemotherapy
Wu, Chenyao; Wang, Shige; Zhao, Jiulong; Liu, Yiyun; Zheng, Yuting; Luo, Yu; Ye, Chongqing; Huang, Mingxian; Chen, Hangrong
2019-06-01
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
Volume29Issue:26
SubtypeArticle
AbstractIn this study, biocompatible Fe(III) species-WS2-polyvinylpyrrolidone (Fe(III) @ WS2-PVP) nanocapsules with enhanced biodegradability and doxorubicin (DOX) loading capacity are one-pot synthesized. In this nanocapsule, there exists a redox reaction between Fe(III) species and WS2 to form Fe2+ and WO42-. The formed Fe2+ could be oxidized to Fe3+, which reacts with Fe(III) @ WS2-PVP again to continuously produce Fe2+ and WO42-. Such a repeated endogenous redox reaction leads to an enhanced biodegradation and DOX release of DOX @ Fe(III) @ WS2-PVP. More strikingly, the Fe2+ generation and DOX release are further accelerated by the overexpressed H2O2 and the mild acidic tumor microenvironment (TME), since H2O2 and H+ can accelerate the oxidation of Fe2+. The continuously generated Fe2+ catalyzes a fast Fenton reaction with the innate H2O2 in tumor cells and produces abundant highly toxic hydroxyl radicals for nanocatalytic tumor therapy. Together with the high photothermal transforming capability, the DOX @ Fe(III) @WS2-PVP nanocapsules successfully achieve the endogenous redox reaction and exogenous TME-augmented tumor photothermal therapy, chemo and nanocatalytic therapy outcome. The concept of material design can be innovatively extended to the synthesis of biodegradable Fe(III) @ MoS2-PVP nanocomposite, thus paving a promising novel way for the rational design of intelligent theranostic agents for highly efficient treatment of cancer.
Keywordbiodegradable Fenton reaction nanocapsules trimodal tumor therapy
DOI10.1002/adfm.201901722
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27067
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Wu, Chenyao,Wang, Shige,Zhao, Jiulong,et al. Biodegradable Fe(III)@WS2-PVP Nanocapsules for Redox Reaction and TME-Enhanced Nanocatalytic, Photothermal, and Chemotherapy[J]. ADVANCED FUNCTIONAL MATERIALS,2019,29(26).
APA Wu, Chenyao.,Wang, Shige.,Zhao, Jiulong.,Liu, Yiyun.,Zheng, Yuting.,...&Chen, Hangrong.(2019).Biodegradable Fe(III)@WS2-PVP Nanocapsules for Redox Reaction and TME-Enhanced Nanocatalytic, Photothermal, and Chemotherapy.ADVANCED FUNCTIONAL MATERIALS,29(26).
MLA Wu, Chenyao,et al."Biodegradable Fe(III)@WS2-PVP Nanocapsules for Redox Reaction and TME-Enhanced Nanocatalytic, Photothermal, and Chemotherapy".ADVANCED FUNCTIONAL MATERIALS 29.26(2019).
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