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Ultrasound-Enhanced Delivery of Doxorubicin-Loaded Nanodiamonds from Pullulan-all-trans-Retinal Nanoparticles for Effective Cancer Therapy
Li, Huanan; Ma, Ming; Zhang, Jingni; Hou, Wei; Chen, Hangrong; Zeng, Deping; Wang, Zhibiao
2019-06-05
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume11Issue:22Pages:20341
SubtypeArticle
AbstractNanodiamond as a drug carrier is of great significance in improving cancer therapy by overcoming chemoresistance: However, its clinical application is severely limited because of insufficient tumor vascular penetration. To address this limitation, pullulan-all-trans-retinal (pullulan-ATR) self-assembled nanoparticles were prepared as nanocarriers, which encapsulated doxorubicin-loaded nanodiamonds, to construct a core-shell structured coloading nanosystem. The obtained composite nanoparticles show a homogeneous size distribution with good dispersity and pH sensitivity. Furthermore, ultrasound was utilized to promote the intratumoral penetration of these nanoparticles. As a result, the intracellular retention of DOX was efficiently enhanced, and DOX in the tumor tissue reached 17.3% of the injected dosage. The antitumor effect of this combined strategy was remarkably improved in both the DOX-sensitive HepG2 and DOX-resistant HepG2/ADR tumor models in vivo. This new strategy might serve as a powerful method to address the limitation of nanodiamonds and provide innovative ideas for the application of nanoparticles in clinical cancer therapy.
Keywordnanodiamonds good dispersity ultrasound nanoparticles cancer therapy
DOI10.1021/acsami.9b03559
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
PublisherAMER CHEMICAL SOC
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27062
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Li, Huanan,Ma, Ming,Zhang, Jingni,et al. Ultrasound-Enhanced Delivery of Doxorubicin-Loaded Nanodiamonds from Pullulan-all-trans-Retinal Nanoparticles for Effective Cancer Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(22):20341.
APA Li, Huanan.,Ma, Ming.,Zhang, Jingni.,Hou, Wei.,Chen, Hangrong.,...&Wang, Zhibiao.(2019).Ultrasound-Enhanced Delivery of Doxorubicin-Loaded Nanodiamonds from Pullulan-all-trans-Retinal Nanoparticles for Effective Cancer Therapy.ACS APPLIED MATERIALS & INTERFACES,11(22),20341.
MLA Li, Huanan,et al."Ultrasound-Enhanced Delivery of Doxorubicin-Loaded Nanodiamonds from Pullulan-all-trans-Retinal Nanoparticles for Effective Cancer Therapy".ACS APPLIED MATERIALS & INTERFACES 11.22(2019):20341.
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