SIC OpenIR
Self-evolved hydrogen peroxide boosts photothermal-promoted tumor-specific nanocatalytic therapy
Gao, Shanshan; Lu, Xiangyu; Zhu, Piao; Lin, Han; Yu, Luodan; Yao, Heliang; Wei, Chenyang; Chen, Yu; Shi, Jianlin
2019-06-14
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume7Issue:22Pages:3599
SubtypeArticle
AbstractThe emerging nanocatalytic tumor therapy such as chemodynamic therapy (CDT) converts less harmful hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (OH) via metal ion-mediated catalytic Fenton chemistry, which has motivated extensive research interest due to the high specificity of the nanocatalytic reactions to the tumor microenvironment (TME) and minimized side effects. However, traditional CDT substantially suffers from the insufficiency of intratumoral H2O2 for inducing a satisfactory therapeutic efficacy. In this work, we report on a photothermally-promoted Fenton reaction triggered by self-supplied H2O2, based on the constructed two-dimensional (2D) multifunctional therapeutic Nb2C-IO-CaO2 nanoreactors with enhanced therapeutic efficacy and therapeutic biosafety. These Nb2C-IO-CaO2 nanoreactors employ calcium peroxide (CaO2) as a potent H2O2 supplier to sustain the iron oxide (IO) nanoparticle-mediated catalytic Fenton reaction, and to liberate highly toxic OH for inducing tumor-cell apoptosis. Meanwhile, the intratumoral OH production was further promoted by the photothermal effect of the Nb2C-IO-CaO2 nanoreactors under near infrared irradiation at the second biowindow. Extensive in vitro and in vivo evaluations have demonstrated significantly enhanced reactive oxygen species (ROS) production and an outstanding photothermal effect based on these Nb2C-IO-CaO2 nanoreactors, which synergistically lead to elevated therapeutic efficacy. Therefore, this work not only exhibits a promising prospect for reforming the TME to achieve enhanced Fenton reactivity for CDT by elaborately designed nanomaterials with multifunctionality, but also provides novel efficient cancer-therapeutic modalities with simultaneous high therapeutic efficacy and low side effects.
DOI10.1039/c9tb00525k
Language英语
WOS Research AreaMaterials Science
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27052
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Gao, Shanshan,Lu, Xiangyu,Zhu, Piao,et al. Self-evolved hydrogen peroxide boosts photothermal-promoted tumor-specific nanocatalytic therapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(22):3599.
APA Gao, Shanshan.,Lu, Xiangyu.,Zhu, Piao.,Lin, Han.,Yu, Luodan.,...&Shi, Jianlin.(2019).Self-evolved hydrogen peroxide boosts photothermal-promoted tumor-specific nanocatalytic therapy.JOURNAL OF MATERIALS CHEMISTRY B,7(22),3599.
MLA Gao, Shanshan,et al."Self-evolved hydrogen peroxide boosts photothermal-promoted tumor-specific nanocatalytic therapy".JOURNAL OF MATERIALS CHEMISTRY B 7.22(2019):3599.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Gao, Shanshan]'s Articles
[Lu, Xiangyu]'s Articles
[Zhu, Piao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Gao, Shanshan]'s Articles
[Lu, Xiangyu]'s Articles
[Zhu, Piao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Gao, Shanshan]'s Articles
[Lu, Xiangyu]'s Articles
[Zhu, Piao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.