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Sequential catalytic nanomedicine augments synergistic chemodrug and chemodynamic cancer therapy
Liang, Ruijie; Chen, Yu; Huo, Minfeng; Zhang, Jun; Li, Yongsheng
2019-07-01
Source PublicationNANOSCALE HORIZONS
ISSN2055-6756
Volume4Issue:4Pages:890
SubtypeArticle
AbstractThe tumor microenvironment (TME) provides intriguing features/indications for rational design of diverse therapeutic protocols with high tumor specificity and therapeutic efficacy. In this work, we report the introduction of the sequential catalytic concept into theranostic nanomedicine for cancer-specific therapy, which has been achieved by the construction of glucose oxidase (GOD) and Mitomycin C (MMC) co-loaded superparamagnetic iron oxide nanoparticles (designated as SMG nanocatalysts). Based on the large amounts of glucose in tumors, the GOD component in SMG catalyzes glucose to convert into hydrogen peroxide (H2O2) and gluconic acid with the simultaneous consumption of oxygen. The post-produced H2O2 is further catalyzed by iron oxide in SMG to produce large amounts of highly toxic hydroxyl radicals for cancer therapy, and the generated gluconic acid enhances such a Fenton-based catalytic reaction. On the other hand, the loaded MMC drug is activated because of the consumption of oxygen and enhanced hypoxia in tumors, causing high chemotherapeutic efficacy. Based on the high synergistic chemodrug and chemodynamic therapeutic efficacy in combating cancer, cancer cells are efficiently killed and tumor growth is thus significantly suppressed. This work paves a new way for cancer therapy by taking into account the full features and advantages of the TME and the physiochemical properties of the chosen nanocatalysts, which also links nanocatalytic science and nanomedicine for proposing new efficient tumor-therapeutic modalities.
DOI10.1039/c9nh00008a
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/27003
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Liang, Ruijie,Chen, Yu,Huo, Minfeng,et al. Sequential catalytic nanomedicine augments synergistic chemodrug and chemodynamic cancer therapy[J]. NANOSCALE HORIZONS,2019,4(4):890.
APA Liang, Ruijie,Chen, Yu,Huo, Minfeng,Zhang, Jun,&Li, Yongsheng.(2019).Sequential catalytic nanomedicine augments synergistic chemodrug and chemodynamic cancer therapy.NANOSCALE HORIZONS,4(4),890.
MLA Liang, Ruijie,et al."Sequential catalytic nanomedicine augments synergistic chemodrug and chemodynamic cancer therapy".NANOSCALE HORIZONS 4.4(2019):890.
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