SIC OpenIR
Rate- controlled nano- layered assembly mechanism of melamine- induced melamine- uric acid stones and its inhibition and elimination methods
Dong, Wenya; Zhang, Yuzhen; Hu, Ping; Xu, Hongwu; Fan, Jie; Su, Jiansheng; Li, Fang; Chen, Yun; Li, Ping; Wang, Shilong; Coe, Fredric L.; Wu, Qingsheng
2019-07-14
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume7Issue:26Pages:4133
SubtypeArticle
AbstractThe outbreak of infant milk powder poisoning in China attracted worldwide attention. The investigations found that the real culprit of this incident was melamine (Mel), which induced the formation of kidney stones. However, little is known about the formation mechanism of infant stones, not to mention the preventive and therapeutic drugs. Here, through thermodynamic and kinetic tests, simulation in vitro and animal experiments, and multidisciplinary analysis and verification, we found that the formation of this kidney stone is a rate-controlled nano-scale supramolecular layered assembly process: Mel, uric acid (UA) and a small amount of H2O combine through hydrogen bonds to form a planar network supramolecular structure; the planar structures self-assemble layer-by-layer to form ellipsoidal nanocrystals through pi-pi stacking interactions, van der Waals force, hydrophilic/hydrophobic interaction, etc.; the small nanocrystals gradually grow and aggregate concentrically to form ellipsoidal Mel-UA stones under the control of the matrix. Based on the above process, we screen out an effective inhibitor and eliminator for stones, potassium citrate (K(3)Cit), which works through both hydrogen bonding and alkalinity. This work solves the most challenging conundrum left by the Mel incident and blazes a trail for the prevention and treatment of kidney stone disease.
DOI10.1039/c9tb00688e
Language英语
WOS Research AreaMaterials Science
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/26980
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Dong, Wenya,Zhang, Yuzhen,Hu, Ping,et al. Rate- controlled nano- layered assembly mechanism of melamine- induced melamine- uric acid stones and its inhibition and elimination methods[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(26):4133.
APA Dong, Wenya.,Zhang, Yuzhen.,Hu, Ping.,Xu, Hongwu.,Fan, Jie.,...&Wu, Qingsheng.(2019).Rate- controlled nano- layered assembly mechanism of melamine- induced melamine- uric acid stones and its inhibition and elimination methods.JOURNAL OF MATERIALS CHEMISTRY B,7(26),4133.
MLA Dong, Wenya,et al."Rate- controlled nano- layered assembly mechanism of melamine- induced melamine- uric acid stones and its inhibition and elimination methods".JOURNAL OF MATERIALS CHEMISTRY B 7.26(2019):4133.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Dong, Wenya]'s Articles
[Zhang, Yuzhen]'s Articles
[Hu, Ping]'s Articles
Baidu academic
Similar articles in Baidu academic
[Dong, Wenya]'s Articles
[Zhang, Yuzhen]'s Articles
[Hu, Ping]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Dong, Wenya]'s Articles
[Zhang, Yuzhen]'s Articles
[Hu, Ping]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.