Rate- controlled nano- layered assembly mechanism of melamine- induced melamine- uric acid stones and its inhibition and elimination methods

doi:10.1039/c9tb00688e

SIC OpenIR

	Rate- controlled nano- layered assembly mechanism of melamine- induced melamine- uric acid stones and its inhibition and elimination methods
	Dong, Wenya; Zhang, Yuzhen; Hu, Ping; Xu, Hongwu; Fan, Jie; Su, Jiansheng; Li, Fang; Chen, Yun; Li, Ping; Wang, Shilong; Coe, Fredric L.; Wu, Qingsheng
	2019-07-14
Source Publication	JOURNAL OF MATERIALS CHEMISTRY B
ISSN	2050-750X
Volume	7 Issue:26 Pages:4133
Subtype	Article
Abstract	The outbreak of infant milk powder poisoning in China attracted worldwide attention. The investigations found that the real culprit of this incident was melamine (Mel), which induced the formation of kidney stones. However, little is known about the formation mechanism of infant stones, not to mention the preventive and therapeutic drugs. Here, through thermodynamic and kinetic tests, simulation in vitro and animal experiments, and multidisciplinary analysis and verification, we found that the formation of this kidney stone is a rate-controlled nano-scale supramolecular layered assembly process: Mel, uric acid (UA) and a small amount of H2O combine through hydrogen bonds to form a planar network supramolecular structure; the planar structures self-assemble layer-by-layer to form ellipsoidal nanocrystals through pi-pi stacking interactions, van der Waals force, hydrophilic/hydrophobic interaction, etc.; the small nanocrystals gradually grow and aggregate concentrically to form ellipsoidal Mel-UA stones under the control of the matrix. Based on the above process, we screen out an effective inhibitor and eliminator for stones, potassium citrate (K(3)Cit), which works through both hydrogen bonding and alkalinity. This work solves the most challenging conundrum left by the Mel incident and blazes a trail for the prevention and treatment of kidney stone disease.
DOI	10.1039/c9tb00688e
Language	英语
WOS Research Area	Materials Science
Publisher	ROYAL SOC CHEMISTRY
Citation statistics	Cited Times:6[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/26980
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Dong, Wenya,Zhang, Yuzhen,Hu, Ping,et al. Rate- controlled nano- layered assembly mechanism of melamine- induced melamine- uric acid stones and its inhibition and elimination methods[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(26):4133.
APA	Dong, Wenya.,Zhang, Yuzhen.,Hu, Ping.,Xu, Hongwu.,Fan, Jie.,...&Wu, Qingsheng.(2019).Rate- controlled nano- layered assembly mechanism of melamine- induced melamine- uric acid stones and its inhibition and elimination methods.JOURNAL OF MATERIALS CHEMISTRY B,7(26),4133.
MLA	Dong, Wenya,et al."Rate- controlled nano- layered assembly mechanism of melamine- induced melamine- uric acid stones and its inhibition and elimination methods".JOURNAL OF MATERIALS CHEMISTRY B 7.26(2019):4133.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Institution:
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh

中国科学院上海硅酸盐研究所机构知识库