Nanocatalysts-augmented Fenton chemical reaction for nanocatalytic tumor therapy

doi:10.1016/j.biomaterials.2019.04.023

SIC OpenIR

	Nanocatalysts-augmented Fenton chemical reaction for nanocatalytic tumor therapy
	Qian, Xiaoqin; Zhang, Jun; Gu, Zi; Chen, Yu
	2019-08-01
Source Publication	BIOMATERIALS
ISSN	0142-9612
Volume	211 Pages:1
Subtype	Review
Abstract	It is the challenging goal in cancer biomedicine to search novel cancer-therapeutic modality with concurrent high therapeutic efficiency on combating cancer and low side effects to normal cells/tissues. The recently developed nanocatalytic cancer therapy based on catalytic Fenton reaction represents one of the promising paradigms for potential clinical translation, which has got fast progress very recently. This progress report discusses the rational design and fabrication of Fenton reaction-based nanocatalysts for triggering the in-situ Fenton chemical reaction within tumor microenvironment to generate highly toxic hydroxyl radicals (center dot OH), which is highly efficient for killing the cancer cells and suppressing the tumor growth. Several strategies for optimizing the nanocatalytic cancer-therapeutic efficiency of Fenton reaction have been highlighted, including screening high-performance Fenton nanocatalysts, increasing peroxide-hydrogen amounts as the reactants, changing the Fenton-reaction conditions (e.g., temperature, acidity and photo-triggering), and Fenton reaction-based synergistic cancer therapy such as some sequential nanocatalytic reactions with improved therapeutic outcome. The facing challenges and future developments of Fenton reaction-based nanocatalytic cancer therapy are also discussed for further promoting the clinical translation of this emerging cancer-therapeutic modality to benefit the cancer patients.
Keyword	Nanocatalytic biomedicine Fenton reaction Nanomedicine Synergistic therapy Cancer
DOI	10.1016/j.biomaterials.2019.04.023
Language	英语
WOS Research Area	Engineering ; Materials Science
Publisher	ELSEVIER SCI LTD
Citation statistics
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/26945
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Qian, Xiaoqin,Zhang, Jun,Gu, Zi,et al. Nanocatalysts-augmented Fenton chemical reaction for nanocatalytic tumor therapy[J]. BIOMATERIALS,2019,211:1.
APA	Qian, Xiaoqin,Zhang, Jun,Gu, Zi,&Chen, Yu.(2019).Nanocatalysts-augmented Fenton chemical reaction for nanocatalytic tumor therapy.BIOMATERIALS,211,1.
MLA	Qian, Xiaoqin,et al."Nanocatalysts-augmented Fenton chemical reaction for nanocatalytic tumor therapy".BIOMATERIALS 211(2019):1.

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