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The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating
Li, Kai; Lu, Xiang; Razanau, Ihar; Wu, Xiaodong; Hu, Tao; Liu, Shiwei; Xie, Youtao; Huang, Liping; Zheng, Xuebin
2019-08-01
Source PublicationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
Volume101Pages:513
SubtypeArticle
AbstractEarly vascularization is crucial for osteogenic repair of bone defects and plays an essential role in the fate of implanted biomaterials. Thus, there is a growing interest in the use of biomaterials to release inorganic ions that are capable of stimulating angiogenesis. Since it has been established that boron (B) may play roles in angiogenesis, the aim of our study was to investigate the in vitro angiogenic effects of the ionic dissolution products from the B-incorporated calcium silicate (Ca11Si4B2O22, B-CS) coating. The results showed that ionic products of B-CS coating extract obviously stimulated the proliferation and migration of human umbilical vein endothelial cells (HUVECs) as well as the in vitro tubule formation when compared with those of CS coating extract. In addition, the gene expression levels of pro-angiogenic growth factors (VEGF, bFGF, ANG1) and receptors (VEGFR-2, bFGFR) were significantly upregulated when stimulated with the B-CS coating extract. Moreover, VEGF and VEGFR-2 protein synthesis, eNOS, and Akt phosphorylation, as well as NO synthesized by HUVECs were increased by the B-CS coating extract. Hence, the B-CS coating offers a potential solution to enhance bone vascularization essential for successful osseointegration of orthopedic implants.
KeywordAngiogenesis Endothelial cells Boron Calcium silicate coating Coating extract
DOI10.1016/j.msec.2019.04.009
Language英语
WOS Research AreaMaterials Science
PublisherELSEVIER
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/26944
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Li, Kai,Lu, Xiang,Razanau, Ihar,et al. The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2019,101:513.
APA Li, Kai.,Lu, Xiang.,Razanau, Ihar.,Wu, Xiaodong.,Hu, Tao.,...&Zheng, Xuebin.(2019).The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,101,513.
MLA Li, Kai,et al."The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 101(2019):513.
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