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Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings
Cui, Mengkui; Wang, Xinyu; An, Bolin; Zhang, Chen; Gui, Xinrui; Li, Ke; Li, Yingfeng; Ge, Peng; Zhang, Junhu; Liu, Cong; Zhong, Chao
2019-08-01
Source PublicationSCIENCE ADVANCES
ISSN2375-2548
Volume5Issue:8
SubtypeArticle
AbstractMany biological materials form via liquid-liquid phase separation (LLPS), followed by maturation into a solid-like state. Here, using a biologically inspired assembly mechanism designed to recapitulate these sequential assemblies, we develop ultrastrong underwater adhesives made from engineered proteins containing mammalian low-complexity (LC) domains. We show that LC domain-mediated LLPS and maturation substantially promotes the wetting, adsorption, priming, and formation of dense, uniform amyloid nanofiber coatings on diverse surfaces (e.g., Teflon), and even penetrating difficult-to-access locations such as the interiors of microfluidic devices. Notably, these coatings can be deposited on substrates over a broad range of pH values (3 to 11) and salt concentrations (up to 1 M NaCl) and exhibit strong underwater adhesion performance. Beyond demonstrating the utility of mammalian LC domains for driving LLPS in soft materials applications, our study illustrates a powerful example of how combining LLPS with subsequent maturation steps can be harnessed for engineering protein-based materials.
DOI10.1126/sciadv.aax3155
Language英语
WOS Research AreaScience & Technology - Other Topics
PublisherAMER ASSOC ADVANCEMENT SCIENCE
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/26928
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Cui, Mengkui,Wang, Xinyu,An, Bolin,et al. Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings[J]. SCIENCE ADVANCES,2019,5(8).
APA Cui, Mengkui.,Wang, Xinyu.,An, Bolin.,Zhang, Chen.,Gui, Xinrui.,...&Zhong, Chao.(2019).Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings.SCIENCE ADVANCES,5(8).
MLA Cui, Mengkui,et al."Exploiting mammalian low-complexity domains for liquid-liquid phase separation-driven underwater adhesive coatings".SCIENCE ADVANCES 5.8(2019).
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