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Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles
Zhang, Meng; Song, Ruixue; Liu, Yanyan; Yi, Zhigao; Meng, Xianfu; Zhang, Jiawen; Tang, Zhongmin; Yao, Zhenwei; Liu, Yang; Liu, Xiaogang; Bu, Wenbo
2019-08-08
Source PublicationCHEM
ISSN2451-9294
Volume5Issue:8Pages:2171
SubtypeArticle
AbstractCalcium overload, characterized by an abnormal cytoplasm accumulation of free calcium ions (Ca2+), is a widely recognized cause of damage in numerous cell types and even of cell death. This undesirable destructive process can become a new tool applicable to cancer treatment. Herein, on the basis of the unique biological effect of Ca2+ we demonstrate a highly efficient strategy for tumor therapy by utilizing pH-sensitive sodium-hyaluronate-modified calcium peroxide nanoparticles (SH-CaO2 NPs). These NPs create an artificial calcium overloading stress in tumor cells, which is responsible for cell death. Notably, the killing effect is not limited to tumor types or hypoxic cells, and normal cells are more tolerant of the adverse influence of NPs than tumor cells. The Ca2+ enrichment also increases the likelihood of tumor calcification, which could contribute to in vivo tumor inhibition and facilitate medical imaging to monitor the treatment efficacy.
DOI10.1016/j.chempr.2019.06.003
Language英语
WOS Research AreaChemistry
PublisherCELL PRESS
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/26914
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Zhang, Meng,Song, Ruixue,Liu, Yanyan,et al. Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles[J]. CHEM,2019,5(8):2171.
APA Zhang, Meng.,Song, Ruixue.,Liu, Yanyan.,Yi, Zhigao.,Meng, Xianfu.,...&Bu, Wenbo.(2019).Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles.CHEM,5(8),2171.
MLA Zhang, Meng,et al."Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles".CHEM 5.8(2019):2171.
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