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Sustained reactive oxygen species generation from percarbamide nanomedicine via a mechanism of X-Ray-initiated free radical chain reactions
Huang, Yongping; Shao, Yiran; Zhu, Yingchun
2019-11-01
Source PublicationJOURNAL OF BIOMATERIALS APPLICATIONS
ISSN0885-3282
Volume34Issue:5Pages:728
SubtypeArticle
AbstractFree radicals are toxic agents known to induce cellular oxidative damage, and reactive oxygen species plays a key role in cancer therapy. Herein, we develop an efficient delivery nanomedicine for controlled free radical generation by loading innocuous percarbamide in chitosan-coated hollow mesoporous silica nanoparticles (PCA@HMSNs-CTS). Reactive oxygen species was generated continuously and kept at a high level during the sustained release process of hydrogen peroxide from PCA@HMSNs-CTS. The evidences for mechanism revealed an autocatalytic free radical chain reactions initiated by a short time soft-X-Ray. The reactive oxygen species intensity in solutions after initiation is 5.8-fold higher than that without soft-X-Ray initiation following with the decomposition of hyperoxides and generation of oxygen. PCA@HMSNs-CTS exhibit a pH-responsive reactive oxygen species release, and the reactive oxygen species exhibit a significant high level in cancer cells which efficiently decrease the cell viability. This work explores the radical generation strategy of percarbamide nanomedicine and is expected to present a new avenue to efficient nanomedicine for cancer therapy.
KeywordPercarbamide nanomedicine free radical chain reactions reactive oxygen species soft-X-Ray cancer therapy
DOI10.1177/0885328219868851
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherSAGE PUBLICATIONS LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/26912
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Huang, Yongping,Shao, Yiran,Zhu, Yingchun. Sustained reactive oxygen species generation from percarbamide nanomedicine via a mechanism of X-Ray-initiated free radical chain reactions[J]. JOURNAL OF BIOMATERIALS APPLICATIONS,2019,34(5):728.
APA Huang, Yongping,Shao, Yiran,&Zhu, Yingchun.(2019).Sustained reactive oxygen species generation from percarbamide nanomedicine via a mechanism of X-Ray-initiated free radical chain reactions.JOURNAL OF BIOMATERIALS APPLICATIONS,34(5),728.
MLA Huang, Yongping,et al."Sustained reactive oxygen species generation from percarbamide nanomedicine via a mechanism of X-Ray-initiated free radical chain reactions".JOURNAL OF BIOMATERIALS APPLICATIONS 34.5(2019):728.
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