Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection

doi:10.1002/adma.201902956

SIC OpenIR

	Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection
	Ni, Dalong; Wei, Hao; Chen, Weiyu; Bao, Qunqun; Rosenkrans, Zachary T.; Barnhart, Todd E.; Ferreira, Carolina A.; Wang, Yanpu; Yao, Heliang; Sun, Tuanwei; Jiang, Dawei; Li, Shiyong; Cao, Tianye; Liu, Zhaofei; Engle, Jonathan W.; Hu, Ping; Lan, Xiaoli; Cai, Weibo
	2019-08-01
Source Publication	ADVANCED MATERIALS
ISSN	0935-9648
Volume	31 Issue:40
Subtype	Article
Abstract	The mononuclear phagocyte system (MPS, e.g., liver, spleen) is often treated as a "blackbox" by nanoresearchers in translating nanomedicines. Often, most of the injected nanomaterials are sequestered by the MPS, preventing their delivery to the desired disease areas. Here, this imperfection is exploited by applying nano-antioxidants with preferential liver uptake to directly prevent hepatic ischemia-reperfusion injury (IRI), which is a reactive oxygen species (ROS)-related disease. Ceria nanoparticles (NPs) are selected as a representative nano-antioxidant and the detailed mechanism of preventing IRI is investigated. It is found that ceria NPs effectively alleviate the clinical symptoms of hepatic IRI by scavenging ROS, inhibiting activation of Kupffer cells and monocyte/macrophage cells. The released pro-inflammatory cytokines are then significantly reduced and the recruitment and infiltration of neutrophils are minimized, which suppress subsequent inflammatory reaction involved in the liver. The protective effect of nano-antioxidants against hepatic IRI in living animals and the revealed mechanism herein suggests their future use for the treatment of hepatic IRI in the clinic.
Keyword	acute livery injury ceria nanoparticles hepatic ischemia-reperfusion injury nano-antixoidants reactive oxygen species
DOI	10.1002/adma.201902956
Language	英语
WOS Research Area	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
Publisher	WILEY-V C H VERLAG GMBH
Citation statistics	Cited Times:18[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/26902
Collection	中国科学院上海硅酸盐研究所
Recommended Citation GB/T 7714	Ni, Dalong,Wei, Hao,Chen, Weiyu,et al. Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection[J]. ADVANCED MATERIALS,2019,31(40).
APA	Ni, Dalong.,Wei, Hao.,Chen, Weiyu.,Bao, Qunqun.,Rosenkrans, Zachary T..,...&Cai, Weibo.(2019).Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection.ADVANCED MATERIALS,31(40).
MLA	Ni, Dalong,et al."Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection".ADVANCED MATERIALS 31.40(2019).

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