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Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection
Ni, Dalong; Wei, Hao; Chen, Weiyu; Bao, Qunqun; Rosenkrans, Zachary T.; Barnhart, Todd E.; Ferreira, Carolina A.; Wang, Yanpu; Yao, Heliang; Sun, Tuanwei; Jiang, Dawei; Li, Shiyong; Cao, Tianye; Liu, Zhaofei; Engle, Jonathan W.; Hu, Ping; Lan, Xiaoli; Cai, Weibo
2019-08-01
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Volume31Issue:40
SubtypeArticle
AbstractThe mononuclear phagocyte system (MPS, e.g., liver, spleen) is often treated as a "blackbox" by nanoresearchers in translating nanomedicines. Often, most of the injected nanomaterials are sequestered by the MPS, preventing their delivery to the desired disease areas. Here, this imperfection is exploited by applying nano-antioxidants with preferential liver uptake to directly prevent hepatic ischemia-reperfusion injury (IRI), which is a reactive oxygen species (ROS)-related disease. Ceria nanoparticles (NPs) are selected as a representative nano-antioxidant and the detailed mechanism of preventing IRI is investigated. It is found that ceria NPs effectively alleviate the clinical symptoms of hepatic IRI by scavenging ROS, inhibiting activation of Kupffer cells and monocyte/macrophage cells. The released pro-inflammatory cytokines are then significantly reduced and the recruitment and infiltration of neutrophils are minimized, which suppress subsequent inflammatory reaction involved in the liver. The protective effect of nano-antioxidants against hepatic IRI in living animals and the revealed mechanism herein suggests their future use for the treatment of hepatic IRI in the clinic.
Keywordacute livery injury ceria nanoparticles hepatic ischemia-reperfusion injury nano-antixoidants reactive oxygen species
DOI10.1002/adma.201902956
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/26902
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Ni, Dalong,Wei, Hao,Chen, Weiyu,et al. Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection[J]. ADVANCED MATERIALS,2019,31(40).
APA Ni, Dalong.,Wei, Hao.,Chen, Weiyu.,Bao, Qunqun.,Rosenkrans, Zachary T..,...&Cai, Weibo.(2019).Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection.ADVANCED MATERIALS,31(40).
MLA Ni, Dalong,et al."Ceria Nanoparticles Meet Hepatic Ischemia-Reperfusion Injury: The Perfect Imperfection".ADVANCED MATERIALS 31.40(2019).
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