SIC OpenIR
A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection
Lin, Zhengjie; Zhao, Ying; Chu, Paul K.; Wang, Luning; Pan, Haobo; Zheng, Yufeng; Wu, Shuilin; Liu, Xuanyong; Cheung, Kenneth M. C.; Wong, Takman; Yeung, Kelvin W. K.
2019-10-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume219
SubtypeArticle
AbstractRapid corrosion of biodegradable magnesium alloys under in vivo condition is a major concern for clinical applications. Inspired by the stability and biocompatibility of titanium oxide (TiO2) passive layer, a functionalized TiO2/Mg2TiO4 nano-layer has been constructed on the surface of WE43 magnesium implant by using plasma ion immersion implantation (PIII) technique. The customized nano-layer not only enhances corrosion resistance of Mg substrates significantly, but also elevates the osteoblastic differentiation capability in vitro due to the controlled release of magnesium ions. In the animal study, the increase of new bone formation adjacent to the PIII-treated magnesium substrate is 175% higher at post-operation 12 weeks, whereas the growth of new bone on titanium control and untreated magnesium substrate are only 97% and 29%, respectively. In addition, its Young's modulus can be restored to about 82% as compared with the surrounding matured bone. Furthermore, this specific TiO2/Mg2TiO4 layer even exhibits photoactive bacteria disinfection capability when irradiated by ultraviolet light which is attributed to the intracellular reactive oxygen species (ROS) production. With all these constructive observations, it is believed that the TiO2/Mg2TiO4 nano-layer on magnesium implants can significantly promote new bone formation and suppress bacterial infection, while the degradation behavior can be controlled simultaneously.
KeywordTitanium oxide nano-layer Biodegradable mg Corrosion resistance Bone regeneration Bacteria disinfection
DOI10.1016/j.biomaterials.2019.119372
Language英语
WOS Research AreaEngineering ; Materials Science
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/26797
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Lin, Zhengjie,Zhao, Ying,Chu, Paul K.,et al. A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection[J]. BIOMATERIALS,2019,219.
APA Lin, Zhengjie.,Zhao, Ying.,Chu, Paul K..,Wang, Luning.,Pan, Haobo.,...&Yeung, Kelvin W. K..(2019).A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection.BIOMATERIALS,219.
MLA Lin, Zhengjie,et al."A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection".BIOMATERIALS 219(2019).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lin, Zhengjie]'s Articles
[Zhao, Ying]'s Articles
[Chu, Paul K.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lin, Zhengjie]'s Articles
[Zhao, Ying]'s Articles
[Chu, Paul K.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lin, Zhengjie]'s Articles
[Zhao, Ying]'s Articles
[Chu, Paul K.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.