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Stimulation of osteogenesis and angiogenesis by micro/nano hierarchical hydroxyapatite via macrophage immunomodulation
Yang, Chen; Zhao, Cancan; Wang, Xiaoya; Shi, Mengchao; Zhu, Yanlun; Jing, Linguo; Wu, Chengtie; Chang, Jiang
2019-10-14
Source PublicationNANOSCALE
ISSN2040-3364
Volume11Issue:38Pages:17699
SubtypeArticle
AbstractBiomaterial topography-based strategies are regarded as an effective way to regulate the osteoimmune environment which plays an indispensable role in the bone regeneration process. The rapid development of manufacture techniques makes it possible to investigate the cell-topography interactions by preparing various micro and nano-topographical surfaces on biomaterials. Still, it is a challenge to prepare well-defined micro/nano hierarchical structures of bioceramics due to the inherent brittleness of ceramic materials. Also, the correlation between osteoimmunomodulation initiated by micro/nano hierarchical topographies and the tissue regeneration outcomes is unclear. In this study, we prepared well-defined micro/nano hierarchical structures on hydroxyapatite (HA) bioceramics through the combination of the photolithography and hydrothermal techniques. Three different microscale circular patterns (4 mu m, 12 mu m and 36 mu m) and nanotopographies (nanoneedle, nanosheet and nanorod) were fabricated by changing the size of the mask and the condition of the hydrothermal reaction. The macrophage responses on the nanoneedle structures with different micropatterns were investigated and the micro/nano hierarchical structures with appropriate pattern sizes could either promote or alleviate the macrophage polarization, which further affected the outcomes of the osteogenic differentiation of human bone marrow stromal cells (hBMSCs) and angiogenic activity of human umbilical vein endothelial cells (HUVECs). Our study demonstrated that osteoimmunomodulation could be manipulated via tuning the micro/nano hierarchical structures, which could lead to a new strategy for the development of bone biomaterials with favorable osteoimmunomodulatory properties.
DOI10.1039/c9nr05730g
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
PublisherROYAL SOC CHEMISTRY
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/26778
Collection中国科学院上海硅酸盐研究所
Recommended Citation
GB/T 7714
Yang, Chen,Zhao, Cancan,Wang, Xiaoya,et al. Stimulation of osteogenesis and angiogenesis by micro/nano hierarchical hydroxyapatite via macrophage immunomodulation[J]. NANOSCALE,2019,11(38):17699.
APA Yang, Chen.,Zhao, Cancan.,Wang, Xiaoya.,Shi, Mengchao.,Zhu, Yanlun.,...&Chang, Jiang.(2019).Stimulation of osteogenesis and angiogenesis by micro/nano hierarchical hydroxyapatite via macrophage immunomodulation.NANOSCALE,11(38),17699.
MLA Yang, Chen,et al."Stimulation of osteogenesis and angiogenesis by micro/nano hierarchical hydroxyapatite via macrophage immunomodulation".NANOSCALE 11.38(2019):17699.
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