Synthesis of carbon coated-ceria with improved cytocompatibility
Chen, Zhaoming; Xie, Youtao; Li, Kai; Huang, Liping; Zheng, Xuebin
AbstractIn this study, we developed a one-step method for the convenient preparation of carbon-coated CeO2 using inductively coupled plasma technology. The carbon-coated CeO2 nanoparticles were obtained using cerium nitrate solution as precursor and ethanol as carbon source. The thickness of the carbon coating was modified by varying the flow rates of oxygen in the sheath gas. The average size of the nanoparticles obtained was around 10 nm, which was similar to that of the uncoated one. However, the content of Ce3+ was slightly increased after the coating with enhanced reactive oxygen species (ROS) scavenging capability. In order to evaluate the cytocompatibility of coated CeO2, two kinds of cell lines, macrophage and keratinocyte, were experimented. The carbon-coated CeO2 exhibited much higher cytocompatibility than that of the uncoated one. Marginal toxicity was found when cells were treated with coated CeO2, whereas the death ratio of macrophages was around 11% after 24 h of treatment with 5 mu g/ml of bare CeO2. Our results indicate that carbon coating may be a promising substitute for polymer modification of CeO2 in order to improve its cytocompatibility and anti-oxidative properties.
KeywordCarbon coated ceria Biomedical application Inductively coupled plasma
WOS Research AreaMaterials Science
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
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GB/T 7714
Chen, Zhaoming,Xie, Youtao,Li, Kai,et al. Synthesis of carbon coated-ceria with improved cytocompatibility[J]. CERAMICS INTERNATIONAL,2019,45(16):19981.
APA Chen, Zhaoming,Xie, Youtao,Li, Kai,Huang, Liping,&Zheng, Xuebin.(2019).Synthesis of carbon coated-ceria with improved cytocompatibility.CERAMICS INTERNATIONAL,45(16),19981.
MLA Chen, Zhaoming,et al."Synthesis of carbon coated-ceria with improved cytocompatibility".CERAMICS INTERNATIONAL 45.16(2019):19981.
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