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A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection
Wang, Jiaxing; Zhou, Huaijuan1; Guo, Geyong; Cheng, Tao; Peng, Xiaochun; Mao, Xin; Li, Jinhua1,2,3; Zhang, Xianlong
2017
发表期刊INTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
卷号12页码:3121
摘要Bloodstream infection, especially with implants involved, is an often life-threatening condition with high mortality rates, imposing a heavy burden on patients and medical systems. Herein, we firstly deposited homogeneous vanadium metal, V2O3, VO2, and V2O5 nanofilms on quartz glass by magnetron sputtering. Using these platforms, we further investigated the potential antimicrobial efficiency of these nano-VOx films and the interactions of human erythrocytes and bacteria ( methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa) with our samples in a novel cell-bacteria coculture model. It was demonstrated that these nano-VOx precipitated favorable antibacterial activity on both bacteria, especially on S. aureus, and this effect increased with higher vanadium valence. A possible mechanism accountable for these results might be elevated levels of vanadium-induced intracellular reactive oxygen species. More importantly, based on hemolysis assays, our nano-VOx films were found to be able to kill prokaryotic cells but were not toxic to mammalian cells, holding the potential for the prevention of implant-related hematogenous infections. As far as we know, this is the first report wherein such nano-VOx films have assisted human erythrocytes to combat bacteria in a valence-dependent manner. Additionally, vanadium ions were released from these nano-VOx films in a sustained manner, and low-valence films possessed better biocompatibility with human fibroblasts. This work may provide new insights for biomedical applications of inorganic vanadium compounds and attract growing attention in this field. From the perspective of surface modification and functionalization, this study holds promise to avail the prophylaxis of bloodstream infections involving implantable biomedical devices.
DOI10.2147/IJN.S129459
WOS记录号WOS:000399791700001
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/26690
专题中国科学院上海硅酸盐研究所
作者单位1.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Orthopaed, 600 Yishan Rd, Shanghai 200233, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai, Peoples R China
3.Univ Hong Kong, Li Ka Shing Fac Med, Dept Orthopaed & Traumatol, Hong Kong, Hong Kong, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
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Wang, Jiaxing,Zhou, Huaijuan,Guo, Geyong,et al. A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2017,12:3121.
APA Wang, Jiaxing.,Zhou, Huaijuan.,Guo, Geyong.,Cheng, Tao.,Peng, Xiaochun.,...&Zhang, Xianlong.(2017).A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection.INTERNATIONAL JOURNAL OF NANOMEDICINE,12,3121.
MLA Wang, Jiaxing,et al."A functionalized surface modification with vanadium nanoparticles of various valences against implant-associated bloodstream infection".INTERNATIONAL JOURNAL OF NANOMEDICINE 12(2017):3121.
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