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Combined chemical and structural signals of biomaterials synergistically activate cell-cell communications for improving tissue regeneration
Xu, Yachen2; Peng, Jinliang1; Dong, Xin2; Xu, Yuhong1; Li, Haiyan2; Chang, Jiang2,3
2017
Source PublicationACTA BIOMATERIALIA
ISSN1742-7061
Volume55Pages:249
AbstractBiomaterials are only used as carriers of cells in the conventional tissue engineering. Considering the multi-cell environment and active cell-biomaterial interactions in tissue regeneration process, in this study, structural signals of aligned electrospun nanofibers and chemical signals of bioglass (BG) ionic products in cell culture medium are simultaneously applied to activate fibroblast-endothelial co-cultured cells in order to obtain an improved skin tissue engineering construct. Results demonstrate that the combined biomaterial signals synergistically activate fibroblast-endothelial co-culture skin tissue engineering constructs through promotion of paracrine effects and stimulation of gap junctional communication between cells, which results in enhanced vascularization and extracellular matrix protein synthesis in the constructs. Structural signals of aligned electrospun nanofibers play an important role in stimulating both of paracrine and gap junctional communication while chemical signals of BG ionic products mainly enhance paracrine effects. In vivo experiments reveal that the activated skin tissue engineering constructs significantly enhance wound healing as compared to control. This study indicates the advantages of synergistic effects between different bioactive signals of biomaterials can be taken to activate communication between different types of cells for obtaining tissue engineering constructs with improved functions. Statement of Significance Tissue engineering can regenerate or replace tissue or organs through combining cells, biomaterials and growth factors. Normally, for repairing a specific tissue, only one type of cells, one kind of biomaterials, and specific growth factors are used to support cell growth. In this study, we proposed a novel tissue engineering approach by simply using co-cultured cells and combined biomaterial signals. Using a skin tissue engineering model, we successfully proved that the combined biomaterial signals such as surface nanostructures and bioactive ions could synergistically stimulate the cell-cell communication in co-culture system through paracrine effects and gap junction activation, and regulated expression of growth factors and extracellular matrix proteins, resulting in an activated tissue engineering constructs that significantly enhanced skin regeneration. (C) 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
DOI10.1016/j.actbio.2017.03.056
WOS IDWOS:000403414500018
EI Accession Number1878-7568
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/26678
Collection中国科学院上海硅酸盐研究所
Affiliation1.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Sch Biomed Engn, 1954 Huashan Rd, Shanghai 200030, Peoples R China
2.Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China
3.Shanghai Jiao Tong Univ, Med X Res Inst, Sch Biomed Engn, 1954 Huashan Rd, Shanghai 200030, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Ceram, 1295 Dingxi Rd, Shanghai 200050, Peoples R China
Recommended Citation
GB/T 7714
Xu, Yachen,Peng, Jinliang,Dong, Xin,et al. Combined chemical and structural signals of biomaterials synergistically activate cell-cell communications for improving tissue regeneration[J]. ACTA BIOMATERIALIA,2017,55:249.
APA Xu, Yachen,Peng, Jinliang,Dong, Xin,Xu, Yuhong,Li, Haiyan,&Chang, Jiang.(2017).Combined chemical and structural signals of biomaterials synergistically activate cell-cell communications for improving tissue regeneration.ACTA BIOMATERIALIA,55,249.
MLA Xu, Yachen,et al."Combined chemical and structural signals of biomaterials synergistically activate cell-cell communications for improving tissue regeneration".ACTA BIOMATERIALIA 55(2017):249.
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