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Microfluidic Encapsulation of Prickly Zinc-Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy
Zhang, Hongbo9; Liu, Dongfei; Wang, Liang2; Liu, Zehua; Wu, Runrun3; Janoniene, Agne4; Ma, Ming5; Pan, Guoqing; Baranauskiene, Lina4; Zhang, Linlin5; Cui, Wenguo6; Petrikaite, Vilma4,7; Matulis, Daumantas4; Zhao, Hongxia1,2; Pan, Jianming3,6,8; Santos, Helder A.
2017
Source PublicationADVANCED HEALTHCARE MATERIALS
ISSN2192-2640
Volume6Issue:11
AbstractStructural features of nanoparticles have recently been explored for different types of applications. To explore specific particles as nanomedicine and physically destroy cancer is interesting, which might avoid many obstacles in cancer treatment, for example, drug resistance. However, one key element and technical challenge of those systems is to selectively target them to cancer cells. As a proof-of-concept, Prickly zinc-doped copper oxide (Zn-CuO) nanoparticles (Prickly NPs) have been synthesized, and subsequently encapsulated in a pH-responsive polymer; and the surface has been modified with a novel synthesized ligand, 3-(cyclooctylamino)2,5,6- trifluoro-4-[(2-hydroxyethyl)-sulfonyl] benzenesulfonamide (VD1142). The Prickly NPs exhibit very effective cancer cell antiproliferative capability. Moreover, the polymer encapsulation shields the Prickly NPs from unspecific nanopiercing and, most importantly, VD1142 endows the engineered NPs to specifically target to the carbonic anhydrase IX, a transmembrane protein overexpressed in a wide variety of cancer tumors. Intracellularly, the Prickly NPs disintegrate into small pieces that upon endosomal escape cause severe damage to the endoplasmic reticulum and mitochondria of the cells. The engineered Prickly NP is promising in efficient and targeted cancer treatment and it opens new avenue in nanomedication.
DOI10.1002/adhm.201601406
WOS IDWOS:000402881700004
EI Accession Number2192-2659
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/26672
Collection中国科学院上海硅酸盐研究所
Affiliation1.[Zhang, Hongbo; Liu, Dongfei; Liu, Zehua; Santos, Helder A.] Univ Helsinki, Fac Pharm, Div Pharmaceut Chem & Technol, FI-00014 Helsinki, Finland
2.Harvard Univ, Harvard John A Paulson Sch Appl Sci & Engn, Cambridge, MA 02138 USA
3.Univ Helsinki, Inst Biotechnol, FI-00014 Helsinki, Finland
4.Jiangsu Univ, Sch Chem & Chem Engn, Zhenjiang 212013, Peoples R China
5.Vilnius Univ, Inst Biotechnol, Dept Biothermodynam & Drug Design, LT-10257 Vilnius, Lithuania
6.Chinese Acad Sci, Shanghai Inst Ceram, Shanghai 200050, Peoples R China
7.Soochow Univ, Orthopaed Inst, Dept Orthopaed, Affiliated Hosp 1, Suzhou 215006, Peoples R China
8.Lithuanian Univ Hlth Sci, Fac Pharm, Dept Drug Chem, LT-44307 Kaunas, Lithuania
9.Stanford Univ, Dept Chem, Stanford, CA 94305 USA
10.Abo Akad Univ, Dept Pharmaceut Sci Lab, FI-20520 Turku, Finland
Recommended Citation
GB/T 7714
Zhang, Hongbo,Liu, Dongfei,Wang, Liang,et al. Microfluidic Encapsulation of Prickly Zinc-Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2017,6(11).
APA Zhang, Hongbo.,Liu, Dongfei.,Wang, Liang.,Liu, Zehua.,Wu, Runrun.,...&Santos, Helder A..(2017).Microfluidic Encapsulation of Prickly Zinc-Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy.ADVANCED HEALTHCARE MATERIALS,6(11).
MLA Zhang, Hongbo,et al."Microfluidic Encapsulation of Prickly Zinc-Doped Copper Oxide Nanoparticles with VD1142 Modified Spermine Acetalated Dextran for Efficient Cancer Therapy".ADVANCED HEALTHCARE MATERIALS 6.11(2017).
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