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Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-beta/Smad Pathway and Osseointegration in Osteopenic Rabbits
Yu, Jiangming4; Xu, Lizhang; Li, Kai1; Xie, Ning; Xi, Yanhai; Wang, Yang; Zheng, Xuebin1; Chen, Xiongsheng; Wang, Meiyan2,3; Ye, Xiaojian
2017
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号7
摘要Surface-modified metal implants incorporating different ions have been employed in the biomedical field as bioactive dental implants with good osseointegration properties. However, the molecular mechanism through which surface coatings exert the biological activity is not fully understood, and the effects have been difficult to achieve, especially in the osteopenic bone. In this study, We examined the effect of zinc-modified calcium silicate coatings with two different Zn contents to induce osteogenic differentiation of rat bone marrow-derived pericytes (BM-PCs) and osteogenetic efficiency in ovariectomised rabbits. Ti-6Al-4V with zinc-modified calcium silicate coatings not only enhanced proliferation but also promoted osteogenic differentiation and mineralized matrix deposition of rat BM-PCs as the zinc content and culture time increased in vitro. The associated molecular mechanisms were investigated by Q-PCR and Western blotting, revealing that TGF-beta/Smad signaling pathway plays a direct and significant role in regulating BM-PCs osteoblastic differentiation on Zn-modified coatings. Furthermore, in vivo results that revealed Zn-modified calcium silicate coatings significantly promoted new bone formation around the implant surface in osteopenic rabbits as the Zn content and exposure time increased. Therefore, Zn-modified calcium silicate coatings can improve implant osseointegration in the condition of osteopenia, which may be beneficial for patients suffering from osteoporosis-related fractures.
DOI10.1038/s41598-017-03661-5
WOS记录号WOS:000403140000111
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/26669
专题中国科学院上海硅酸盐研究所
作者单位1.Second Mil Med Univ, Dept Orthopaed, Changzheng Hosp, Shanghai 200003, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Ceram, Key Lab Inorgan Coating Mat, Shanghai 200050, Peoples R China
3.East China Normal Univ, Shanghai Key Lab Regulatory Biol, Inst Biomed Sci, Shanghai 200241, Peoples R China
4.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China
5.Natl Engn Res Ctr Nanotechnol, Shanghai 200241, Peoples R China
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Yu, Jiangming,Xu, Lizhang,Li, Kai,et al. Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-beta/Smad Pathway and Osseointegration in Osteopenic Rabbits[J]. SCIENTIFIC REPORTS,2017,7.
APA Yu, Jiangming.,Xu, Lizhang.,Li, Kai.,Xie, Ning.,Xi, Yanhai.,...&Ye, Xiaojian.(2017).Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-beta/Smad Pathway and Osseointegration in Osteopenic Rabbits.SCIENTIFIC REPORTS,7.
MLA Yu, Jiangming,et al."Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-beta/Smad Pathway and Osseointegration in Osteopenic Rabbits".SCIENTIFIC REPORTS 7(2017).
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