Sealing the Pores of PEO Coating with Mg-Al Layered Double Hydroxide: Enhanced Corrosion Resistance, Cytocompatibility and Drug Delivery Ability

doi:10.1038/s41598-017-08238-w

SIC OpenIR

	Sealing the Pores of PEO Coating with Mg-Al Layered Double Hydroxide: Enhanced Corrosion Resistance, Cytocompatibility and Drug Delivery Ability
	Peng, Feng 1; Wang, Donghui 1; Tian, Yaxin 1; Cao, Huiliang ; Qiao, Yuqin ; Liu, Xuanyong
	2017
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	7
摘要	In recent years, magnesium (Mg) alloys show a promising application in clinic as degradable biomaterials. Nevertheless, the poor corrosion resistance of Mg alloys is the main obstacle to their clinical application. Here we successfully seal the pores of plasma electrolytic oxidation (PEO) coating on AZ31 with Mg-Al layered double hydroxide (LDH) via hydrothermal treatment. PEO/LDH composite coating possess a two layer structure, an inner layer made up of PEO coating (similar to 5 mu m) and an outer layer of Mg-Al LDH (similar to 2 mu m). Electrochemical and hydrogen evolution tests suggest preferable corrosion resistance of the PEO/LDH coating. Cytotoxicity, cell adhesion, live/dead staining and proliferation data of rat bone marrow stem cells (rBMSCs) demonstrate that PEO/LDH coating remarkably enhance the cytocompatibility of the substrate, indicating a potential application in orthopedic surgeries. In addition, hemolysis rate (HR) test shows that the HR value of PEO/LDH coating is 1.10 +/- 0.47%, fulfilling the request of clinical application. More importantly, the structure of Mg-Al LDH on the top of PEO coating shows excellent drug delivery ability.
DOI	10.1038/s41598-017-08238-w
WOS记录号	WOS:000407570000044
引用统计	被引频次：11[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.sic.ac.cn/handle/331005/26655
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Peng, Feng,Wang, Donghui,Tian, Yaxin,et al. Sealing the Pores of PEO Coating with Mg-Al Layered Double Hydroxide: Enhanced Corrosion Resistance, Cytocompatibility and Drug Delivery Ability[J]. SCIENTIFIC REPORTS,2017,7.
APA	Peng, Feng,Wang, Donghui,Tian, Yaxin,Cao, Huiliang,Qiao, Yuqin,&Liu, Xuanyong.(2017).Sealing the Pores of PEO Coating with Mg-Al Layered Double Hydroxide: Enhanced Corrosion Resistance, Cytocompatibility and Drug Delivery Ability.SCIENTIFIC REPORTS,7.
MLA	Peng, Feng,et al."Sealing the Pores of PEO Coating with Mg-Al Layered Double Hydroxide: Enhanced Corrosion Resistance, Cytocompatibility and Drug Delivery Ability".SCIENTIFIC REPORTS 7(2017).