Sealing the Pores of PEO Coating with Mg-Al Layered Double Hydroxide: Enhanced Corrosion Resistance, Cytocompatibility and Drug Delivery Ability

doi:10.1038/s41598-017-08238-w

SIC OpenIR

	Sealing the Pores of PEO Coating with Mg-Al Layered Double Hydroxide: Enhanced Corrosion Resistance, Cytocompatibility and Drug Delivery Ability
	Peng, Feng 1; Wang, Donghui 1; Tian, Yaxin 1; Cao, Huiliang ; Qiao, Yuqin ; Liu, Xuanyong
	2017
Source Publication	SCIENTIFIC REPORTS
ISSN	2045-2322
Volume	7
Abstract	In recent years, magnesium (Mg) alloys show a promising application in clinic as degradable biomaterials. Nevertheless, the poor corrosion resistance of Mg alloys is the main obstacle to their clinical application. Here we successfully seal the pores of plasma electrolytic oxidation (PEO) coating on AZ31 with Mg-Al layered double hydroxide (LDH) via hydrothermal treatment. PEO/LDH composite coating possess a two layer structure, an inner layer made up of PEO coating (similar to 5 mu m) and an outer layer of Mg-Al LDH (similar to 2 mu m). Electrochemical and hydrogen evolution tests suggest preferable corrosion resistance of the PEO/LDH coating. Cytotoxicity, cell adhesion, live/dead staining and proliferation data of rat bone marrow stem cells (rBMSCs) demonstrate that PEO/LDH coating remarkably enhance the cytocompatibility of the substrate, indicating a potential application in orthopedic surgeries. In addition, hemolysis rate (HR) test shows that the HR value of PEO/LDH coating is 1.10 +/- 0.47%, fulfilling the request of clinical application. More importantly, the structure of Mg-Al LDH on the top of PEO coating shows excellent drug delivery ability.
DOI	10.1038/s41598-017-08238-w
WOS ID	WOS:000407570000044
Citation statistics	Cited Times:12[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/26655
Collection	中国科学院上海硅酸盐研究所
Affiliation	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation GB/T 7714	Peng, Feng,Wang, Donghui,Tian, Yaxin,et al. Sealing the Pores of PEO Coating with Mg-Al Layered Double Hydroxide: Enhanced Corrosion Resistance, Cytocompatibility and Drug Delivery Ability[J]. SCIENTIFIC REPORTS,2017,7.
APA	Peng, Feng,Wang, Donghui,Tian, Yaxin,Cao, Huiliang,Qiao, Yuqin,&Liu, Xuanyong.(2017).Sealing the Pores of PEO Coating with Mg-Al Layered Double Hydroxide: Enhanced Corrosion Resistance, Cytocompatibility and Drug Delivery Ability.SCIENTIFIC REPORTS,7.
MLA	Peng, Feng,et al."Sealing the Pores of PEO Coating with Mg-Al Layered Double Hydroxide: Enhanced Corrosion Resistance, Cytocompatibility and Drug Delivery Ability".SCIENTIFIC REPORTS 7(2017).

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