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Coordination-Accelerated "Iron Extraction" Enables Fast Biodegradation of Mesoporous Silica-Based Hollow Nanoparticles
Wang, Liying1,2; Huo, Minfeng2; Chen, Yu; Shi, Jianlin
2017
发表期刊ADVANCED HEALTHCARE MATERIALS
ISSN2192-2640
卷号6期号:22
摘要Biodegradation behavior of inorganic silica-based nanoplatforms is of critical importance in their clinical translations, but still remains a great challenge in achieving this goal by composition regulation of biocompatible silica framework. In the present work, a chemical coordination-accelerated biodegradation strategy to endow hollow mesoporous silica nanoparticles (HMSNs) with unique coordination-responsive biodegradability, on-demand coordination-responsive drug releasing behavior, and significantly enhanced chemotherapeutic efficacy by directly doping iron (Fe) ions into the framework of mesoporous silica is reported. A simple but versatile dissolution-regrowth strategy has been developed to enable the framework Fe doping via chemical bonding. The deferiprone-mediated biodegradation of Fe-doped HMSNs (Fe-HMSNs) has been comprehensively evaluated both in simulated body fluid and intracellular level, which have exhibited a specific coordination-accelerated biodegradation behavior. In addition to high biocompatibility of Fe-HMSNs, the anticancer drug doxorubicin (DOX)-loaded Fe-HMSNs show enhanced tumor-suppressing effect on 4T1 mammary cancer xenograft. This work paves a new way for tuning the biodegradation performance of mesoporous silica-based nanoplatforms simply by biocompatible Fe-ion doping into silica framework based on the specific coordination property between introduced metal Fe ions with Fe-coordination proteins.
DOI10.1002/adhm.201700720
WOS记录号WOS:000416122200011
EI入藏号2192-2659
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文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/26626
专题中国科学院上海硅酸盐研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
2.ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Wang, Liying,Huo, Minfeng,Chen, Yu,et al. Coordination-Accelerated "Iron Extraction" Enables Fast Biodegradation of Mesoporous Silica-Based Hollow Nanoparticles[J]. ADVANCED HEALTHCARE MATERIALS,2017,6(22).
APA Wang, Liying,Huo, Minfeng,Chen, Yu,&Shi, Jianlin.(2017).Coordination-Accelerated "Iron Extraction" Enables Fast Biodegradation of Mesoporous Silica-Based Hollow Nanoparticles.ADVANCED HEALTHCARE MATERIALS,6(22).
MLA Wang, Liying,et al."Coordination-Accelerated "Iron Extraction" Enables Fast Biodegradation of Mesoporous Silica-Based Hollow Nanoparticles".ADVANCED HEALTHCARE MATERIALS 6.22(2017).
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