SIC OpenIR
Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents
Ni, Dalong1; Bu, Wenbo1; Ehlerding, Emily B.; Cai, Weibo2,3; Shi, Jianlin1
2017
Source PublicationCHEMICAL SOCIETY REVIEWS
ISSN0306-0012
Volume46Issue:23Pages:7438
AbstractMagnetic resonance imaging (MRI) is a highly valuable non-invasive imaging tool owing to its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide clinical applicability. Contrast agents (CAs) can be used to further enhance the sensitivity of MRI to obtain information-rich images. Recently, extensive research efforts have been focused on the design and synthesis of high-performance inorganic nanoparticle-based CAs to improve the quality and specificity of MRI. Herein, the basic rules, including the choice of metal ions, effect of electron motion on water relaxation, and involved mechanisms, of CAs for MRI have been elucidated in detail. In particular, various design principles, including size control, surface modification (e.g. organic ligand, silica shell, and inorganic nanolayers), and shape regulation, to impact relaxation of water molecules have been discussed in detail. Comprehensive understanding of how these factors work can guide the engineering of future inorganic nanoparticles with high relaxivity. Finally, we have summarized the currently available strategies and their mechanism for obtaining high-performance CAs and discussed the challenges and future developments of nanoparticulate CAs for clinical translation in MRI.
DOI10.1039/c7cs00316a
WOS IDWOS:000417020300016
EI Accession Number1460-4744
Citation statistics
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/26619
Collection中国科学院上海硅酸盐研究所
Affiliation1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
2.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
3.Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA
4.Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA
Recommended Citation
GB/T 7714
Ni, Dalong,Bu, Wenbo,Ehlerding, Emily B.,et al. Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents[J]. CHEMICAL SOCIETY REVIEWS,2017,46(23):7438.
APA Ni, Dalong,Bu, Wenbo,Ehlerding, Emily B.,Cai, Weibo,&Shi, Jianlin.(2017).Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents.CHEMICAL SOCIETY REVIEWS,46(23),7438.
MLA Ni, Dalong,et al."Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents".CHEMICAL SOCIETY REVIEWS 46.23(2017):7438.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ni, Dalong]'s Articles
[Bu, Wenbo]'s Articles
[Ehlerding, Emily B.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ni, Dalong]'s Articles
[Bu, Wenbo]'s Articles
[Ehlerding, Emily B.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ni, Dalong]'s Articles
[Bu, Wenbo]'s Articles
[Ehlerding, Emily B.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.