SIC OpenIR
Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents
Ni, Dalong1; Bu, Wenbo1; Ehlerding, Emily B.; Cai, Weibo2,3; Shi, Jianlin1
2017
发表期刊CHEMICAL SOCIETY REVIEWS
ISSN0306-0012
卷号46期号:23页码:7438
摘要Magnetic resonance imaging (MRI) is a highly valuable non-invasive imaging tool owing to its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide clinical applicability. Contrast agents (CAs) can be used to further enhance the sensitivity of MRI to obtain information-rich images. Recently, extensive research efforts have been focused on the design and synthesis of high-performance inorganic nanoparticle-based CAs to improve the quality and specificity of MRI. Herein, the basic rules, including the choice of metal ions, effect of electron motion on water relaxation, and involved mechanisms, of CAs for MRI have been elucidated in detail. In particular, various design principles, including size control, surface modification (e.g. organic ligand, silica shell, and inorganic nanolayers), and shape regulation, to impact relaxation of water molecules have been discussed in detail. Comprehensive understanding of how these factors work can guide the engineering of future inorganic nanoparticles with high relaxivity. Finally, we have summarized the currently available strategies and their mechanism for obtaining high-performance CAs and discussed the challenges and future developments of nanoparticulate CAs for clinical translation in MRI.
DOI10.1039/c7cs00316a
WOS记录号WOS:000417020300016
EI入藏号1460-4744
引用统计
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/26619
专题中国科学院上海硅酸盐研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
2.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
3.Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA
4.Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA
推荐引用方式
GB/T 7714
Ni, Dalong,Bu, Wenbo,Ehlerding, Emily B.,et al. Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents[J]. CHEMICAL SOCIETY REVIEWS,2017,46(23):7438.
APA Ni, Dalong,Bu, Wenbo,Ehlerding, Emily B.,Cai, Weibo,&Shi, Jianlin.(2017).Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents.CHEMICAL SOCIETY REVIEWS,46(23),7438.
MLA Ni, Dalong,et al."Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents".CHEMICAL SOCIETY REVIEWS 46.23(2017):7438.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ni, Dalong]的文章
[Bu, Wenbo]的文章
[Ehlerding, Emily B.]的文章
百度学术
百度学术中相似的文章
[Ni, Dalong]的文章
[Bu, Wenbo]的文章
[Ehlerding, Emily B.]的文章
必应学术
必应学术中相似的文章
[Ni, Dalong]的文章
[Bu, Wenbo]的文章
[Ehlerding, Emily B.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。