Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

doi:10.1039/c7cs00316a

SIC OpenIR

	Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents
	Ni, Dalong 1; Bu, Wenbo 1; Ehlerding, Emily B.; Cai, Weibo 2,3; Shi, Jianlin 1
	2017
发表期刊	CHEMICAL SOCIETY REVIEWS
ISSN	0306-0012
卷号	46 期号:23 页码:7438
摘要	Magnetic resonance imaging (MRI) is a highly valuable non-invasive imaging tool owing to its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide clinical applicability. Contrast agents (CAs) can be used to further enhance the sensitivity of MRI to obtain information-rich images. Recently, extensive research efforts have been focused on the design and synthesis of high-performance inorganic nanoparticle-based CAs to improve the quality and specificity of MRI. Herein, the basic rules, including the choice of metal ions, effect of electron motion on water relaxation, and involved mechanisms, of CAs for MRI have been elucidated in detail. In particular, various design principles, including size control, surface modification (e.g. organic ligand, silica shell, and inorganic nanolayers), and shape regulation, to impact relaxation of water molecules have been discussed in detail. Comprehensive understanding of how these factors work can guide the engineering of future inorganic nanoparticles with high relaxivity. Finally, we have summarized the currently available strategies and their mechanism for obtaining high-performance CAs and discussed the challenges and future developments of nanoparticulate CAs for clinical translation in MRI.
DOI	10.1039/c7cs00316a
WOS记录号	WOS:000417020300016
EI入藏号	1460-4744
引用统计
文献类型	期刊论文
条目标识符	http://ir.sic.ac.cn/handle/331005/26619
专题	中国科学院上海硅酸盐研究所
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China 3.Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA 4.Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA
推荐引用方式 GB/T 7714	Ni, Dalong,Bu, Wenbo,Ehlerding, Emily B.,et al. Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents[J]. CHEMICAL SOCIETY REVIEWS,2017,46(23):7438.
APA	Ni, Dalong,Bu, Wenbo,Ehlerding, Emily B.,Cai, Weibo,&Shi, Jianlin.(2017).Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents.CHEMICAL SOCIETY REVIEWS,46(23),7438.
MLA	Ni, Dalong,et al."Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents".CHEMICAL SOCIETY REVIEWS 46.23(2017):7438.