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A Versatile Carbonic Anhydrase IX Targeting Ligand-Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging
Janoniene, Agne1,2; Liu, Zehua2; Baranauskiene, Lina1; Mäkilä, Ermei3; Ma, Ming4; Salonen, Jarno3; Hirvonen, Jouni2; Zhang, Hongbo2,5; Petrikaite, Vilma1,6; Santos, Hélder A.2
2017
Source PublicationACS Applied Materials and Interfaces
ISSN19448244
Volume9Issue:16Pages:13976-13987
AbstractHypoxia occurs in most solid tumors, and it has been shown to be an independent prognostic indicator of a poor clinical outcome for patients with various cancers. Therefore, constructing a nanosystem specifically targeting cancer cells under hypoxia conditions is a promising approach for cancer therapy. Herein, we develop a porous silicon (PSi)-based nanosystem for targeted cancer therapy. VD11-4-2, a novel inhibitor for carbonic anhydrase IX (CA IX), is anchored on PSi particles (VD-PSi). As CA IX is mainly expressed on the cancer cell membrane under hypoxia condition, this nanocomplex inherits a strong affinity toward hypoxic human breast adenocarcinoma (MCF-7) cells; thus, a better killing efficiency for the hypoxia-induced drug resistance cancer cell is observed. Furthermore, the release of doxorubicin (DOX) from VD-PSi showed pH dependence, which is possibly due to the hydrogen-bonding interaction between DOX and VD11-4-2. The fluorescence resonance energy transfer effect between DOX and VD11-4-2 is observed and applied for monitoring the DOX release intracellularly. Protein inhibition and binding assays showed that VD-PSi binds and inhibits CA IX. Overall, we developed a novel nanosystem inheriting several advantageous properties, which has great potential for targeted treatment of cancer cells under hypoxic conditions. © 2017 American Chemical Society.
DOI10.1021/acsami.7b04038
EI Accession Number20171803613905
EI KeywordsCarbonic anhydrase
EI Classification Number461.2 Biological Materials and Tissue Engineering - 461.6 Medicine and Pharmacology - 549.3 Nonferrous Metals and Alloys excluding Alkali and Alkaline Earth Metals - 761 Nanotechnology - 801.2 Biochemistry - 801.4 Physical Chemistry - 933 Solid State Physics
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Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25943
Collection中国科学院上海硅酸盐研究所
Affiliation1.Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Vilnius University, Vilnius; LT-10257, Lithuania;
2.Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki, Helsinki; FI-00014, Finland;
3.Laboratory of Industrial Physics, Department of Physics, University of Turku, Turku; FI-20014, Finland;
4.Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
5.Department of Pharmaceutical Science, Åbo Akademi University, Turku; FI-20520, Finland;
6.Department of Drug Chemistry, Faculty of Pharmacy, Lithuanian University of Health Sciences, Kaunas; LT-44307, Lithuania
Recommended Citation
GB/T 7714
Janoniene, Agne,Liu, Zehua,Baranauskiene, Lina,et al. A Versatile Carbonic Anhydrase IX Targeting Ligand-Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging[J]. ACS Applied Materials and Interfaces,2017,9(16):13976-13987.
APA Janoniene, Agne.,Liu, Zehua.,Baranauskiene, Lina.,Mäkilä, Ermei.,Ma, Ming.,...&Santos, Hélder A..(2017).A Versatile Carbonic Anhydrase IX Targeting Ligand-Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging.ACS Applied Materials and Interfaces,9(16),13976-13987.
MLA Janoniene, Agne,et al."A Versatile Carbonic Anhydrase IX Targeting Ligand-Functionalized Porous Silicon Nanoplatform for Dual Hypoxia Cancer Therapy and Imaging".ACS Applied Materials and Interfaces 9.16(2017):13976-13987.
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