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Three-dimensional porous graphene nanosheets synthesized on the titanium surface for osteogenic differentiation of rat bone mesenchymal stem cells
Qiu, Jiajun1,3; Guo, Jingshu1,3; Geng, Hao1,3; Qian, Wenhao2; Liu, Xuanyong1
2017
Source PublicationCarbon
ISSN00086223
Volume125Pages:227-235
AbstractCurrently, graphene and its derivatives, used for surface modification of orthopedic and dental implants, are mainly in the form of two-dimensional planar structure. There is little information of three dimensional porous graphene nanosheets used as coating materials of titanium and its alloys. In the present study, three dimensional porous graphene nanosheets were first synthesized on the pure titanium surface. The physicochemical properties and osteogenic activity of the three dimensional porous graphene nanosheets-modified titanium (rGO@Ti) were systematically investigated. The results suggested that rGO@Ti showed super hydrophilicity, rough surface and excellent biocompatibility, and could enhance alkaline phosphatase (ALP) activity, extracellular matrix (ECM) mineralization and collagen secretion of rat bone mesenchymal stem cells (rBMSCs). Meanwhile, the expressions of osteogenesis related genes containing ALP, bone morphogenic protein-2 (BMP-2), osteocalcin (OCN), and osteopontin (OPN) on rGO@Ti were improved. The osteogenic differentiation of rBMSCs on rGO@Ti may be ascribed to both its superior protein adsorption ability and physical stimulation induced by the unique structure of three dimensional porous graphene nanosheets. © 2017 Elsevier Ltd
DOI10.1016/j.carbon.2017.09.064
EI Accession Number20173904200569
EI KeywordsTitanium alloys
EI Classification Number461 Bioengineering and Biology - 462.3 Dental Equipment and Supplies - 542.3 Titanium and Alloys - 761 Nanotechnology - 804 Chemical Products Generally - 933 Solid State Physics
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25910
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.Shanghai Xuhui District Dental Center, Shanghai; 200032, China;
3.University of Chinese Academy of Sciences, Beijing; 100049, China
Recommended Citation
GB/T 7714
Qiu, Jiajun,Guo, Jingshu,Geng, Hao,et al. Three-dimensional porous graphene nanosheets synthesized on the titanium surface for osteogenic differentiation of rat bone mesenchymal stem cells[J]. Carbon,2017,125:227-235.
APA Qiu, Jiajun,Guo, Jingshu,Geng, Hao,Qian, Wenhao,&Liu, Xuanyong.(2017).Three-dimensional porous graphene nanosheets synthesized on the titanium surface for osteogenic differentiation of rat bone mesenchymal stem cells.Carbon,125,227-235.
MLA Qiu, Jiajun,et al."Three-dimensional porous graphene nanosheets synthesized on the titanium surface for osteogenic differentiation of rat bone mesenchymal stem cells".Carbon 125(2017):227-235.
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