SIC OpenIR
Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing
Wang, Xiaocheng1,2; Lv, Fang3; Li, Tian1,2; Han, Yiming3; Yi, Zhengfang3; Liu, Mingyao3; Chang, Jiang1; Wu, Chengtie1
2017
发表期刊ACS Nano
ISSN19360851
卷号11期号:11页码:11337-11349
摘要Surgical excision of skin cancers can hardly remove the tumor tissues completely and simultaneously result in cutaneous defects. To avoid tumor recurrence and heal the tumor-induced wounds, we designed a tissue engineering membrane possessing bifunctions of tumor therapy and skin tissue regeneration. The micropatterned nanocomposite membrane was successfully fabricated by incorporating Cu2S nanoflowers into biopolymer fibers via a modified electrospinning method. With uniformly embedded Cu2S nanoparticles, the membranes exhibited excellent and controllable photothermal performance under near-infrared irradiation, which resulted in high mortality (>90%) of skin tumor cells and effectively inhibited tumor growth in mice. Moreover, the membranes supported the adhesion, proliferation, and migration of skin cells as well as significantly stimulated angiogenesis and healed full-thickness skin defects in vivo. This proof-of-concept study offers a facile and reliable strategy for localized skin tumor therapy and tissue regeneration using bifunctional tissue engineering biomaterials, showing great promise for tumor-induced wound healing applications. © 2017 American Chemical Society.
DOI10.1021/acsnano.7b05858
EI入藏号20174904487536
EI主题词Tissue regeneration
EI分类号461.1 Biomedical Engineering - 461.2 Biological Materials and Tissue Engineering - 462.5 Biomaterials (including synthetics) - 761 Nanotechnology - 819.3 Fiber Chemistry and Processing - 951 Materials Science
引用统计
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25902
专题中国科学院上海硅酸盐研究所
作者单位1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China;
2.University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing; 100049, China;
3.Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai; 200241, China
推荐引用方式
GB/T 7714
Wang, Xiaocheng,Lv, Fang,Li, Tian,et al. Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing[J]. ACS Nano,2017,11(11):11337-11349.
APA Wang, Xiaocheng.,Lv, Fang.,Li, Tian.,Han, Yiming.,Yi, Zhengfang.,...&Wu, Chengtie.(2017).Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing.ACS Nano,11(11),11337-11349.
MLA Wang, Xiaocheng,et al."Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing".ACS Nano 11.11(2017):11337-11349.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Xiaocheng]的文章
[Lv, Fang]的文章
[Li, Tian]的文章
百度学术
百度学术中相似的文章
[Wang, Xiaocheng]的文章
[Lv, Fang]的文章
[Li, Tian]的文章
必应学术
必应学术中相似的文章
[Wang, Xiaocheng]的文章
[Lv, Fang]的文章
[Li, Tian]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。