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Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing
Wang, Xiaocheng1,2; Lv, Fang3; Li, Tian1,2; Han, Yiming3; Yi, Zhengfang3; Liu, Mingyao3; Chang, Jiang1; Wu, Chengtie1
2017
Source PublicationACS Nano
ISSN19360851
Volume11Issue:11Pages:11337-11349
AbstractSurgical excision of skin cancers can hardly remove the tumor tissues completely and simultaneously result in cutaneous defects. To avoid tumor recurrence and heal the tumor-induced wounds, we designed a tissue engineering membrane possessing bifunctions of tumor therapy and skin tissue regeneration. The micropatterned nanocomposite membrane was successfully fabricated by incorporating Cu2S nanoflowers into biopolymer fibers via a modified electrospinning method. With uniformly embedded Cu2S nanoparticles, the membranes exhibited excellent and controllable photothermal performance under near-infrared irradiation, which resulted in high mortality (>90%) of skin tumor cells and effectively inhibited tumor growth in mice. Moreover, the membranes supported the adhesion, proliferation, and migration of skin cells as well as significantly stimulated angiogenesis and healed full-thickness skin defects in vivo. This proof-of-concept study offers a facile and reliable strategy for localized skin tumor therapy and tissue regeneration using bifunctional tissue engineering biomaterials, showing great promise for tumor-induced wound healing applications. © 2017 American Chemical Society.
DOI10.1021/acsnano.7b05858
EI Accession Number20174904487536
EI KeywordsTissue regeneration
EI Classification Number461.1 Biomedical Engineering - 461.2 Biological Materials and Tissue Engineering - 462.5 Biomaterials (including synthetics) - 761 Nanotechnology - 819.3 Fiber Chemistry and Processing - 951 Materials Science
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Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25902
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China;
2.University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing; 100049, China;
3.Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai; 200241, China
Recommended Citation
GB/T 7714
Wang, Xiaocheng,Lv, Fang,Li, Tian,et al. Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing[J]. ACS Nano,2017,11(11):11337-11349.
APA Wang, Xiaocheng.,Lv, Fang.,Li, Tian.,Han, Yiming.,Yi, Zhengfang.,...&Wu, Chengtie.(2017).Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing.ACS Nano,11(11),11337-11349.
MLA Wang, Xiaocheng,et al."Electrospun Micropatterned Nanocomposites Incorporated with Cu2S Nanoflowers for Skin Tumor Therapy and Wound Healing".ACS Nano 11.11(2017):11337-11349.
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