SIC OpenIR
Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles
Cao, Huiliang1; Zhang, Wenjie2; Meng, Fanhao1; Guo, Jinshu1; Wang, Donghui1; Qian, Shi1; Jiang, Xinquan2; Liu, Xuanyong1; Chu, Paul K.3
2017
Source PublicationACS Applied Materials and Interfaces
ISSN19448244
Volume9Issue:6Pages:5149-5157
AbstractSilver nanoparticles (Ag NPs) were widely explored for antimicrobial applications, whereas the translation into drugs and implantable antibacterial devices provoked serious concerns about their potential cytotoxicity. Herein, Ag NPs with diameters ranging from 4 to 19 nm were in situ fabricated and immobilized on titanium by using a plasma immersion ion implantation process. The particles have a population-dependent capability in activating the integrin α5 orchestrated MAPK/ERK signal cascade of osteoblast differentiation in rat bone marrow stem cells (BMSCs), and promoting osteointegration of titanium. It was demonstrated that the titanium-supported Ag NPs played an important role in motivating integrin α5 through triggering the galvanic hydrogen evolution reactions, which was found in positive correlation with the distribution density of the immobilized Ag NPs. Since cellular uptake is a key factor determining the cytotoxic performance of Ag NPs, the extracellular effects of immobilized Ag NPs on promoting osteogenesis provided new insights into the safe application of nanomaterials, and into designing and developing renewed antibacterial devices with selective toxicity. © 2017 American Chemical Society.
DOI10.1021/acsami.6b15448
EI Accession Number20170803367320
EI KeywordsSilver nanoparticles
EI Classification Number461.2 Biological Materials and Tissue Engineering - 461.9 Biology - 542.3 Titanium and Alloys - 547.1 Precious Metals - 761 Nanotechnology - 921.2 Calculus - 932.3 Plasma Physics
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25893
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.Department of Prosthodontics, School of Medicine, Ninth People's Hospital Affiliated, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai; 200011, China;
3.Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong
Recommended Citation
GB/T 7714
Cao, Huiliang,Zhang, Wenjie,Meng, Fanhao,et al. Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles[J]. ACS Applied Materials and Interfaces,2017,9(6):5149-5157.
APA Cao, Huiliang.,Zhang, Wenjie.,Meng, Fanhao.,Guo, Jinshu.,Wang, Donghui.,...&Chu, Paul K..(2017).Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles.ACS Applied Materials and Interfaces,9(6),5149-5157.
MLA Cao, Huiliang,et al."Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles".ACS Applied Materials and Interfaces 9.6(2017):5149-5157.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cao, Huiliang]'s Articles
[Zhang, Wenjie]'s Articles
[Meng, Fanhao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cao, Huiliang]'s Articles
[Zhang, Wenjie]'s Articles
[Meng, Fanhao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cao, Huiliang]'s Articles
[Zhang, Wenjie]'s Articles
[Meng, Fanhao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.