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Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles
Cao, Huiliang1; Zhang, Wenjie2; Meng, Fanhao1; Guo, Jinshu1; Wang, Donghui1; Qian, Shi1; Jiang, Xinquan2; Liu, Xuanyong1; Chu, Paul K.3
2017
发表期刊ACS Applied Materials and Interfaces
ISSN19448244
卷号9期号:6页码:5149-5157
摘要Silver nanoparticles (Ag NPs) were widely explored for antimicrobial applications, whereas the translation into drugs and implantable antibacterial devices provoked serious concerns about their potential cytotoxicity. Herein, Ag NPs with diameters ranging from 4 to 19 nm were in situ fabricated and immobilized on titanium by using a plasma immersion ion implantation process. The particles have a population-dependent capability in activating the integrin α5 orchestrated MAPK/ERK signal cascade of osteoblast differentiation in rat bone marrow stem cells (BMSCs), and promoting osteointegration of titanium. It was demonstrated that the titanium-supported Ag NPs played an important role in motivating integrin α5 through triggering the galvanic hydrogen evolution reactions, which was found in positive correlation with the distribution density of the immobilized Ag NPs. Since cellular uptake is a key factor determining the cytotoxic performance of Ag NPs, the extracellular effects of immobilized Ag NPs on promoting osteogenesis provided new insights into the safe application of nanomaterials, and into designing and developing renewed antibacterial devices with selective toxicity. © 2017 American Chemical Society.
DOI10.1021/acsami.6b15448
EI入藏号20170803367320
EI主题词Silver nanoparticles
EI分类号461.2 Biological Materials and Tissue Engineering - 461.9 Biology - 542.3 Titanium and Alloys - 547.1 Precious Metals - 761 Nanotechnology - 921.2 Calculus - 932.3 Plasma Physics
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25893
专题中国科学院上海硅酸盐研究所
作者单位1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.Department of Prosthodontics, School of Medicine, Ninth People's Hospital Affiliated, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai; 200011, China;
3.Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong
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Cao, Huiliang,Zhang, Wenjie,Meng, Fanhao,et al. Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles[J]. ACS Applied Materials and Interfaces,2017,9(6):5149-5157.
APA Cao, Huiliang.,Zhang, Wenjie.,Meng, Fanhao.,Guo, Jinshu.,Wang, Donghui.,...&Chu, Paul K..(2017).Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles.ACS Applied Materials and Interfaces,9(6),5149-5157.
MLA Cao, Huiliang,et al."Osteogenesis Catalyzed by Titanium-Supported Silver Nanoparticles".ACS Applied Materials and Interfaces 9.6(2017):5149-5157.
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