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Enhanced Bioactivity and Bacteriostasis of Surface Fluorinated Polyetheretherketone
Chen, Meiling1; Ouyang, Liping2,3; Lu, Tao2; Wang, Heying2; Meng, Fanhao2; Yang, Yan1; Ning, Congqin2; Ma, Jingzhi1; Liu, Xuanyong2
2017
发表期刊ACS Applied Materials and Interfaces
ISSN19448244
卷号9期号:20页码:16824-16833
摘要Although polyetheretherketone (PEEK) has been considered as a potential orthopedic and dental application material due to its similar elastic modulus as bones, inferior osseointegration and bacteriostasis of PEEK hampers its clinical application. In this work, fluorinated PEEK was constructed via plasma immersion ion implantation (PIII) followed by hydrofluoric acid treatment to ameliorate the osseointegration and antibacterial properties of PEEK. The surface microstructure, composition, and hydrophilicity of all samples were investigated. Rat bone mesenchymal stem cells (rBMSCs) were cultured on their surfaces to estimate bioactivity. The fluorinated PEEK can enhance the cell adhesion, cell spreading, proliferation, and alkaline phosphatase (ALP) activity compared to pristine PEEK. Furthermore, the fluorinated PEEK surface exhibits good bacteriostatic effect against Porphyromonas gingivalis, which is one of the major periodontal pathogens. In summary, we provide an effective route to introduce fluorine and the results reveal that the fluorinated PEEK can enhance the osseointegration and bacteriostasis, which provides a potential candidate for dental implants. © 2017 American Chemical Society.
DOI10.1021/acsami.7b02521
EI入藏号20172203709690
EI主题词Ion implantation
EI分类号461.2 Biological Materials and Tissue Engineering - 461.9 Biology - 462.3 Dental Equipment and Supplies - 802.2 Chemical Reactions - 804 Chemical Products Generally - 804.2 Inorganic Compounds - 815.1.1 Organic Polymers - 932.3 Plasma Physics
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文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25882
专题中国科学院上海硅酸盐研究所
作者单位1.Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;
2.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
3.University of Chinese Academy of Science, Beijing; 100049, China
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Chen, Meiling,Ouyang, Liping,Lu, Tao,et al. Enhanced Bioactivity and Bacteriostasis of Surface Fluorinated Polyetheretherketone[J]. ACS Applied Materials and Interfaces,2017,9(20):16824-16833.
APA Chen, Meiling.,Ouyang, Liping.,Lu, Tao.,Wang, Heying.,Meng, Fanhao.,...&Liu, Xuanyong.(2017).Enhanced Bioactivity and Bacteriostasis of Surface Fluorinated Polyetheretherketone.ACS Applied Materials and Interfaces,9(20),16824-16833.
MLA Chen, Meiling,et al."Enhanced Bioactivity and Bacteriostasis of Surface Fluorinated Polyetheretherketone".ACS Applied Materials and Interfaces 9.20(2017):16824-16833.
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