Enhanced Bioactivity and Bacteriostasis of Surface Fluorinated Polyetheretherketone
Chen, Meiling1; Ouyang, Liping2,3; Lu, Tao2; Wang, Heying2; Meng, Fanhao2; Yang, Yan1; Ning, Congqin2; Ma, Jingzhi1; Liu, Xuanyong2
Source PublicationACS Applied Materials and Interfaces
AbstractAlthough polyetheretherketone (PEEK) has been considered as a potential orthopedic and dental application material due to its similar elastic modulus as bones, inferior osseointegration and bacteriostasis of PEEK hampers its clinical application. In this work, fluorinated PEEK was constructed via plasma immersion ion implantation (PIII) followed by hydrofluoric acid treatment to ameliorate the osseointegration and antibacterial properties of PEEK. The surface microstructure, composition, and hydrophilicity of all samples were investigated. Rat bone mesenchymal stem cells (rBMSCs) were cultured on their surfaces to estimate bioactivity. The fluorinated PEEK can enhance the cell adhesion, cell spreading, proliferation, and alkaline phosphatase (ALP) activity compared to pristine PEEK. Furthermore, the fluorinated PEEK surface exhibits good bacteriostatic effect against Porphyromonas gingivalis, which is one of the major periodontal pathogens. In summary, we provide an effective route to introduce fluorine and the results reveal that the fluorinated PEEK can enhance the osseointegration and bacteriostasis, which provides a potential candidate for dental implants. © 2017 American Chemical Society.
EI Accession Number20172203709690
EI KeywordsIon implantation
EI Classification Number461.2 Biological Materials and Tissue Engineering - 461.9 Biology - 462.3 Dental Equipment and Supplies - 802.2 Chemical Reactions - 804 Chemical Products Generally - 804.2 Inorganic Compounds - 815.1.1 Organic Polymers - 932.3 Plasma Physics
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Document Type期刊论文
Affiliation1.Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;
2.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
3.University of Chinese Academy of Science, Beijing; 100049, China
Recommended Citation
GB/T 7714
Chen, Meiling,Ouyang, Liping,Lu, Tao,et al. Enhanced Bioactivity and Bacteriostasis of Surface Fluorinated Polyetheretherketone[J]. ACS Applied Materials and Interfaces,2017,9(20):16824-16833.
APA Chen, Meiling.,Ouyang, Liping.,Lu, Tao.,Wang, Heying.,Meng, Fanhao.,...&Liu, Xuanyong.(2017).Enhanced Bioactivity and Bacteriostasis of Surface Fluorinated Polyetheretherketone.ACS Applied Materials and Interfaces,9(20),16824-16833.
MLA Chen, Meiling,et al."Enhanced Bioactivity and Bacteriostasis of Surface Fluorinated Polyetheretherketone".ACS Applied Materials and Interfaces 9.20(2017):16824-16833.
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