Enhanced osteogenic activity of anatase TiO2film: Surface hydroxyl groups induce conformational changes in fibronectin

doi:10.1016/j.msec.2017.04.056

SIC OpenIR

	Enhanced osteogenic activity of anatase TiO2film: Surface hydroxyl groups induce conformational changes in fibronectin
	Lv, Lin 1,2; Li, Kai 1; Xie, Youtao 1; Cao, Yunzhen 1; Zheng, Xuebin 1
	2017
Source Publication	Materials Science and Engineering C
ISSN	09284931
Volume	78 Pages:96-104
Abstract	In this study, with an attempt to identify the effects of TiO2crystalline phase compositions on the osteogenic properties, the anatase and rutile TiO2thin films with similar film thickness, surface topography and hydrophilicity were prepared on Si (100) substrates by atomic layer deposition (ALD), subsequent thermal annealing and ultraviolet irradiation. The films were studied with XRD, XPS, FE-SEM, AFM, FTIR and contact angle measurements. In vitro cellular assays showed that the anatase phase led to better osteoblast compatibility in terms of adhesion, proliferation, differentiation, mineralization as well as osteogenesis-related gene expression when compared with the rutile phase. We investigated the difference between the anatase and rutile TiO2films at the biomolecular level to explain the enhanced osteogenic activity of the anatase film. It was found that the presence of more Ti[sbnd]OH groups on anatase surface induced more cell-binding sites of fibronectin (FN) exposed on its surface, causing a more active conformation of the adsorbed FN for subsequent osteoblast behaviors. © 2017
DOI	10.1016/j.msec.2017.04.056
EI Accession Number	20171603578276
EI Keywords	Titanium dioxide
EI Classification Number	461.9 Biology - 482.2 Minerals - 801.2 Biochemistry - 804.2 Inorganic Compounds - 813.1 Coating Techniques - 931.2 Physical Properties of Gases, Liquids and Solids - 951 Materials Science
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Document Type	期刊论文
Identifier	http://ir.sic.ac.cn/handle/331005/25866
Collection	中国科学院上海硅酸盐研究所
Corresponding Author	Cao, Yunzhen
Affiliation	1.Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China; 2.University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing; 100049, China
Recommended Citation GB/T 7714	Lv, Lin,Li, Kai,Xie, Youtao,et al. Enhanced osteogenic activity of anatase TiO2film: Surface hydroxyl groups induce conformational changes in fibronectin[J]. Materials Science and Engineering C,2017,78:96-104.
APA	Lv, Lin,Li, Kai,Xie, Youtao,Cao, Yunzhen,&Zheng, Xuebin.(2017).Enhanced osteogenic activity of anatase TiO2film: Surface hydroxyl groups induce conformational changes in fibronectin.Materials Science and Engineering C,78,96-104.
MLA	Lv, Lin,et al."Enhanced osteogenic activity of anatase TiO2film: Surface hydroxyl groups induce conformational changes in fibronectin".Materials Science and Engineering C 78(2017):96-104.

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