SIC OpenIR
Enhanced osteogenic activity of anatase TiO2film: Surface hydroxyl groups induce conformational changes in fibronectin
Lv, Lin1,2; Li, Kai1; Xie, Youtao1; Cao, Yunzhen1; Zheng, Xuebin1
2017
发表期刊Materials Science and Engineering C
ISSN09284931
卷号78页码:96-104
摘要In this study, with an attempt to identify the effects of TiO2crystalline phase compositions on the osteogenic properties, the anatase and rutile TiO2thin films with similar film thickness, surface topography and hydrophilicity were prepared on Si (100) substrates by atomic layer deposition (ALD), subsequent thermal annealing and ultraviolet irradiation. The films were studied with XRD, XPS, FE-SEM, AFM, FTIR and contact angle measurements. In vitro cellular assays showed that the anatase phase led to better osteoblast compatibility in terms of adhesion, proliferation, differentiation, mineralization as well as osteogenesis-related gene expression when compared with the rutile phase. We investigated the difference between the anatase and rutile TiO2films at the biomolecular level to explain the enhanced osteogenic activity of the anatase film. It was found that the presence of more Ti[sbnd]OH groups on anatase surface induced more cell-binding sites of fibronectin (FN) exposed on its surface, causing a more active conformation of the adsorbed FN for subsequent osteoblast behaviors. © 2017
DOI10.1016/j.msec.2017.04.056
EI入藏号20171603578276
EI主题词Titanium dioxide
EI分类号461.9 Biology - 482.2 Minerals - 801.2 Biochemistry - 804.2 Inorganic Compounds - 813.1 Coating Techniques - 931.2 Physical Properties of Gases, Liquids and Solids - 951 Materials Science
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文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25866
专题中国科学院上海硅酸盐研究所
通讯作者Cao, Yunzhen
作者单位1.Key Laboratory of Inorganic Coating Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China;
2.University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing; 100049, China
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GB/T 7714
Lv, Lin,Li, Kai,Xie, Youtao,et al. Enhanced osteogenic activity of anatase TiO2film: Surface hydroxyl groups induce conformational changes in fibronectin[J]. Materials Science and Engineering C,2017,78:96-104.
APA Lv, Lin,Li, Kai,Xie, Youtao,Cao, Yunzhen,&Zheng, Xuebin.(2017).Enhanced osteogenic activity of anatase TiO2film: Surface hydroxyl groups induce conformational changes in fibronectin.Materials Science and Engineering C,78,96-104.
MLA Lv, Lin,et al."Enhanced osteogenic activity of anatase TiO2film: Surface hydroxyl groups induce conformational changes in fibronectin".Materials Science and Engineering C 78(2017):96-104.
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