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Preparation and enhanced mechanical properties of hybrid hydrogels comprising ultralong hydroxyapatite nanowires and sodium alginate
Jiang, Ying-Ying1,2; Zhu, Ying-Jie1,2; Li, Heng1,2; Zhang, Yong-Gang1,2; Shen, Yue-Qin1,2; Sun, Tuan-Wei1,2; Chen, Feng1,2
2017
发表期刊Journal of Colloid and Interface Science
ISSN00219797
卷号497页码:266-275
摘要Hydrogels with 3-dimentional cross-linked structures are widely used in various biomedical fields such as bone repair scaffolds, drug carriers and biosensors. However, the applications of hydrogels are usually restricted because of their poor mechanical properties. Currently, nanocomposites, double network systems, hydrophobic association, macromolecules, and nanoparticles are commonly adopted as cross-linking agents to enhance mechanical properties of hydrogels. In this work, ultralong hydroxyapatite nanowires (HANWs) with lengths of several hundred microns are prepared and used to enhance the mechanical properties of sodium alginate (SA)-based hydrogels. Using divalent calcium ions as the cross-linking agent, the hybrid HANWs/SA hydrogels containing various percentages of HANWs are obtained. The as-prepared HANWs/SA hybrid hydrogels have a porous structure with pore sizes ranging from about 200 to 500 μm. The mechanical properties of SA hydrogels can be significantly improved by incorporating HANWs. The maximum compressive modulus (E50%) and tensile Young's modulus of the hybrid hydrogel (HANWs/SA = 2:1) are as high as 0.123 MPa and 0.994 MPa, which are about 162% and 614% those of the pure SA hydrogel, respectively. Due to the enhanced mechanical properties and high biocompatibility, the as-prepared HANWs/SA hybrid hydrogels have promising applications in various biomedical fields such as bone defect repair. © 2017 Elsevier Inc.
DOI10.1016/j.jcis.2017.03.032
EI入藏号20171103441319
EI主题词Hydrogels
EI分类号405.1 Construction Equipment - 461.2 Biological Materials and Tissue Engineering - 461.9.1 Immunology - 549.1 Alkali Metals - 761 Nanotechnology - 802.2 Chemical Reactions - 804 Chemical Products Generally - 913.5 Maintenance - 933 Solid State Physics - 951 Materials Science
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25854
专题中国科学院上海硅酸盐研究所
通讯作者Zhu, Ying-Jie
作者单位1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.University of Chinese Academy of Sciences, Beijing; 100049, China
推荐引用方式
GB/T 7714
Jiang, Ying-Ying,Zhu, Ying-Jie,Li, Heng,et al. Preparation and enhanced mechanical properties of hybrid hydrogels comprising ultralong hydroxyapatite nanowires and sodium alginate[J]. Journal of Colloid and Interface Science,2017,497:266-275.
APA Jiang, Ying-Ying.,Zhu, Ying-Jie.,Li, Heng.,Zhang, Yong-Gang.,Shen, Yue-Qin.,...&Chen, Feng.(2017).Preparation and enhanced mechanical properties of hybrid hydrogels comprising ultralong hydroxyapatite nanowires and sodium alginate.Journal of Colloid and Interface Science,497,266-275.
MLA Jiang, Ying-Ying,et al."Preparation and enhanced mechanical properties of hybrid hydrogels comprising ultralong hydroxyapatite nanowires and sodium alginate".Journal of Colloid and Interface Science 497(2017):266-275.
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