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Metalloporphyrin-encapsulated biodegradable nanosystems for highly efficient magnetic resonance imaging-guided sonodynamic cancer therapy
Huang, Ping1; Qian, Xiaoqin3; Chen, Yu2; Yu, Luodan2; Lin, Han2; Wang, Liying2; Zhu, Yufang1; Shi, Jianlin2
2017
发表期刊Journal of the American Chemical Society
ISSN00027863
卷号139期号:3页码:1275-1284
摘要Traditional photodynamic therapy (PDT) suffers from the critical issues of low tissue-penetrating depth of light and potential phototoxicity, which are expected to be solved by developing new dynamic therapy-based therapeutic modalities such as sonodynamic therapy (SDT). In this work, we report on the design/fabrication of a high-performance multifunctional nanoparticulate sonosensitizer for efficient in vivo magnetic resonance imaging (MRI)-guided SDT against cancer. The developed approach takes the structural and compositional features of mesoporous organosilica-based nanosystems for the fabrication of sonosensitizers with intriguing theranostic performance. The welldefined mesoporosity facilitates the high loading of organic sonosensitizers (protoporphyrin, PpDi) and further chelating of paramagnetic transitional metal Mn ions based on metalloporphyrin chemistry (MnPpIX). The mesoporous structure of large surface area also maximizes the accessibility of water molecules to the encapsulated paramagnetic Mn ions, endowing the composite sonosensitizers with markedly high MRI performance (rl= 9.43 mM-1s-2) for SDT guidance and monitoring. Importantly, the developed multifunctional sonosensitizers (HMONs-MnPpIX-PEG) with controllable biodegradation behavior and high biocompatibility show distinctively high SDT efficiency for inducing the cancer-cell death in vitro and suppressing the tumor growth in vivo. This report provides a paradigm that nanotechnology-enhanced SDT based on elaborately designed highperformance multifunctional sonosensitizers will pave a new way for efficient cancer treatment by fully taking the advantages (noninvasiveness, convenience, cost-effectiveness, etc.) of ultrasound therapy and quickly developing nanomedicine. © 2016 American Chemical Society.
DOI10.1021/jacs.6b11846
EI入藏号20172003665669
EI主题词Nanosystems
EI分类号445.1 Water Treatment Techniques - 461 Bioengineering and Biology - 543.2 Manganese and Alloys - 701.2 Magnetism: Basic Concepts and Phenomena - 751 Acoustics, Noise. Sound - 761 Nanotechnology - 804.1 Organic Compounds - 911.2 Industrial Economics - 931.3 Atomic and Molecular Physics - 933 Solid State Physics
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文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25842
专题中国科学院上海硅酸盐研究所
作者单位1.School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai; 200093, China;
2.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
3.Department of Ultrasound, Affiliated People's Hospital, Jiangsu University, Zhenjiang; 212002, China
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Huang, Ping,Qian, Xiaoqin,Chen, Yu,et al. Metalloporphyrin-encapsulated biodegradable nanosystems for highly efficient magnetic resonance imaging-guided sonodynamic cancer therapy[J]. Journal of the American Chemical Society,2017,139(3):1275-1284.
APA Huang, Ping.,Qian, Xiaoqin.,Chen, Yu.,Yu, Luodan.,Lin, Han.,...&Shi, Jianlin.(2017).Metalloporphyrin-encapsulated biodegradable nanosystems for highly efficient magnetic resonance imaging-guided sonodynamic cancer therapy.Journal of the American Chemical Society,139(3),1275-1284.
MLA Huang, Ping,et al."Metalloporphyrin-encapsulated biodegradable nanosystems for highly efficient magnetic resonance imaging-guided sonodynamic cancer therapy".Journal of the American Chemical Society 139.3(2017):1275-1284.
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