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Copper-doped mesoporous hydroxyapatite microspheres synthesized by a microwave-hydrothermal method using creatine phosphate as an organic phosphorus source: application in drug delivery and enhanced bone regeneration
Yu, Weilin1; Sun, Tuan-Wei2,3; Ding, Zhenyu1; Qi, Chao2,3; Zhao, Huakun1; Chen, Feng2,3; Shi, Zhongmin1; Zhu, Ying-Jie2,3; Chen, Daoyun1; He, Yaohua1,4
2017
Source PublicationJournal of Materials Chemistry B
ISSN20507518
Volume5Issue:5Pages:1039-1052
AbstractThe development of multifunctional biomaterials with drug delivery ability, and pro-osteogenic and pro-angiogenic activities has garnered increasing interest in the field of regenerative medicine. In the present study, hypoxia-mimicking copper (Cu)-doped mesoporous hydroxyapatite (HAP) microspheres (Cu-MHMs) were successfully synthesized through a microwave-hydrothermal method by using creatine phosphate as an organic phosphorus source. The Cu-MHMs doped with 0.2, 0.5 and 1 mol% Cu were prepared. The Cu-MHMs consisting of HAP nanorods or nanosheets exhibited a hierarchically mesoporous hollow structure and a high specific surface area. Then the Cu-MHMs were investigated as a drug nanocarrier using doxorubicin hydrochloride (DOX) as a model drug. The Cu-MHMs showed a relatively high drug-loading capacity and a pH-responsive drug release behavior. Furthermore, the Cu-MHMs were incorporated into a chitosan (CS) matrix to construct a biomimetic scaffold optimized for bone regeneration. The Cu-MHM/CS composite scaffolds maintained high degrees of porosity and showed a sustained release of Cu ions. More importantly, the Cu-MHM/CS scaffolds not only enhanced the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBMSCs) but also promoted the migration and tube formation of EA.hy926 cells. When implanted in rat critical-sized calvarial defects, the Cu-MHM/CS scaffolds significantly enhanced bone regeneration accompanied by more new blood vessel formation at 8 weeks post-operation compared with the MHM/CS scaffolds. These results suggest that the hypoxia-mimicking Cu-MHM/CS scaffolds could encourage bone regeneration by enhancing osteogenesis and angiogenesis simultaneously, which bodes well for the reconstruction of vascularized tissue-engineered bone. © The Royal Society of Chemistry.
DOI10.1039/c6tb02747d
EI Accession Number20170603327619
EI KeywordsCopper compounds
EI Classification Number461 Bioengineering and Biology - 462.5 Biomaterials (including synthetics) - 544.1 Copper - 761 Nanotechnology - 804 Chemical Products Generally - 804.2 Inorganic Compounds - 933 Solid State Physics
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Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25824
Collection中国科学院上海硅酸盐研究所
Affiliation1.Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai; 200233, China;
2.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China;
3.University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing; 100049, China;
4.Shanghai Jiao Tong University Affiliated Sixth People's Hospital, School of Biomedical Engineering, 600 Yishan Road, Shanghai; 200233, China
Recommended Citation
GB/T 7714
Yu, Weilin,Sun, Tuan-Wei,Ding, Zhenyu,et al. Copper-doped mesoporous hydroxyapatite microspheres synthesized by a microwave-hydrothermal method using creatine phosphate as an organic phosphorus source: application in drug delivery and enhanced bone regeneration[J]. Journal of Materials Chemistry B,2017,5(5):1039-1052.
APA Yu, Weilin.,Sun, Tuan-Wei.,Ding, Zhenyu.,Qi, Chao.,Zhao, Huakun.,...&He, Yaohua.(2017).Copper-doped mesoporous hydroxyapatite microspheres synthesized by a microwave-hydrothermal method using creatine phosphate as an organic phosphorus source: application in drug delivery and enhanced bone regeneration.Journal of Materials Chemistry B,5(5),1039-1052.
MLA Yu, Weilin,et al."Copper-doped mesoporous hydroxyapatite microspheres synthesized by a microwave-hydrothermal method using creatine phosphate as an organic phosphorus source: application in drug delivery and enhanced bone regeneration".Journal of Materials Chemistry B 5.5(2017):1039-1052.
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