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Preparation and in vivo evaluation of a silicate-based composite bone cement
Ma, Bing1; Huan, Zhiguang1; Xu, Chen1; Ma, Nan2; Zhu, Haibo2; Zhong, Jipin3; Chang, Jiang1
2017
Source PublicationJournal of Biomaterials Applications
ISSN08853282
Volume32Issue:2Pages:257-264
AbstractSilicate-based cements have been developed as a class of bioactive and biodegradable bone cements owing to their good in vitro bioactivity and ability to dissolve in a simulated body fluid. Until recently, however, the in vivo evidence of their ability to support bone regeneration is still scarce. In the present study, a pilot in vivo evaluation of a silicate-based composite bone cement (CSC) was carried out in a rabbit femur defect model. The cement was composed of tricalcium silicate, 45S5 bioglass and calcium sulfate, and the self-setting properties of the material were established. The in vivo bone integration and biodegradability of CSC were investigated and compared with those of bioactive glass particulates, and a calcium phosphate cement. The results showed that CSC underwent a relatively slower in vivo degradation as compared with bioactive glass and calcium phosphate cement. Histological observation demonstrated that bone contact area at the interface between the surrounding bone and CSC gradually increased with time proceeding. CSC kept its structural integrity during implantation in vivo because of its acceptable mechanical strength. These results provide evidence of effectiveness in vivo and suggest potential clinical applications of the silicate-based composite bone cements. © The Author(s) 2017.
DOI10.1177/0885328217715428
EI Accession Number20173003980472
EI KeywordsBone cement
EI Classification Number412.1 Cement - 461.2 Biological Materials and Tissue Engineering - 461.9.1 Immunology - 462.5 Biomaterials (including synthetics) - 482.2 Minerals - 801.2 Biochemistry - 803 Chemical Agents and Basic Industrial Chemicals
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25797
Collection中国科学院上海硅酸盐研究所
Affiliation1.Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China;
2.Central Hospital of Xuhui District, Shanghai, China;
3.Yancheng Beiersheng Biotecnology Co. Ltd, Jiangsu, China
Recommended Citation
GB/T 7714
Ma, Bing,Huan, Zhiguang,Xu, Chen,et al. Preparation and in vivo evaluation of a silicate-based composite bone cement[J]. Journal of Biomaterials Applications,2017,32(2):257-264.
APA Ma, Bing.,Huan, Zhiguang.,Xu, Chen.,Ma, Nan.,Zhu, Haibo.,...&Chang, Jiang.(2017).Preparation and in vivo evaluation of a silicate-based composite bone cement.Journal of Biomaterials Applications,32(2),257-264.
MLA Ma, Bing,et al."Preparation and in vivo evaluation of a silicate-based composite bone cement".Journal of Biomaterials Applications 32.2(2017):257-264.
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