SIC OpenIR
Elemental bio-imaging of PEGylated NaYF4:Yb/Tm/Gd upconversion nanoparticles in mice by laser ablation inductively coupled plasma mass spectrometry to study toxic side effects on the spleen, liver and kidneys
Li, Qing; Wang, Zheng; Chen, Yirui; Zhang, Guoxia
2017
发表期刊Metallomics
ISSN17565901
卷号9期号:8页码:1150-1156
摘要Rare-earth upconversion nanoparticles (UCNPs) are considered stable nanoprobes with low toxicity and deep tissue penetration. However, the increasing use of UCNPs has raised concerns about their potential toxicity in living organisms. Very few studies have reported the toxicity of UCNPs; hence, it is not possible to conclude yet that UCNPs are safe. In this study, the distribution of PEGylated NaYF4:Yb/Tm/Gd nanoparticles (PEG-UCNPs) in female Balb/c mice following intravenous administration, and imaging in the spleen, liver and kidney was examined by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). PEG-UCNPs distributed primarily to the liver and spleen, with significant but lower levels being noted in the kidneys, heart, and lungs. At the sub-organ level, PEG-UCNPs mainly accumulated within the red pulp of the spleen instead of the white pulp, which indicated that PEG-UCNPs are poorly immunogenic, or not immunogenic at all. The imaging of Cu in the liver and spleen showed that the primary clearance organ for PEG-UCNPs is the liver, although they are accumulated in the spleen rather than the liver. This can be explained by the fact that excess superoxide anions produced by phagocytosis of the PEG-UCNPs need Cu-Zn-superoxide dismutase to be converted to hydrogen peroxide. From the Fe, Cu, and Zn imaging of the kidney, it was concluded that PEG-UCNPs do not exhibit nephrotoxicity. © The Royal Society of Chemistry 2017.
DOI10.1039/c7mt00132k
EI入藏号20173404056108
EI主题词Laser ablation
EI分类号461.7 Health Care - 461.9.1 Immunology - 547.2 Rare Earth Metals - 641.2 Heat Transfer - 761 Nanotechnology - 801 Chemistry - 804.2 Inorganic Compounds - 932.3 Plasma Physics - 933 Solid State Physics
引用统计
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25777
专题中国科学院上海硅酸盐研究所
作者单位Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China
推荐引用方式
GB/T 7714
Li, Qing,Wang, Zheng,Chen, Yirui,et al. Elemental bio-imaging of PEGylated NaYF4:Yb/Tm/Gd upconversion nanoparticles in mice by laser ablation inductively coupled plasma mass spectrometry to study toxic side effects on the spleen, liver and kidneys[J]. Metallomics,2017,9(8):1150-1156.
APA Li, Qing,Wang, Zheng,Chen, Yirui,&Zhang, Guoxia.(2017).Elemental bio-imaging of PEGylated NaYF4:Yb/Tm/Gd upconversion nanoparticles in mice by laser ablation inductively coupled plasma mass spectrometry to study toxic side effects on the spleen, liver and kidneys.Metallomics,9(8),1150-1156.
MLA Li, Qing,et al."Elemental bio-imaging of PEGylated NaYF4:Yb/Tm/Gd upconversion nanoparticles in mice by laser ablation inductively coupled plasma mass spectrometry to study toxic side effects on the spleen, liver and kidneys".Metallomics 9.8(2017):1150-1156.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Qing]的文章
[Wang, Zheng]的文章
[Chen, Yirui]的文章
百度学术
百度学术中相似的文章
[Li, Qing]的文章
[Wang, Zheng]的文章
[Chen, Yirui]的文章
必应学术
必应学术中相似的文章
[Li, Qing]的文章
[Wang, Zheng]的文章
[Chen, Yirui]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。