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A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows
Lin, Han1,2; Gao, Shanshan1,2; Dai, Chen1; Chen, Yu1; Shi, Jianlin1
2017
发表期刊Journal of the American Chemical Society
ISSN00027863
卷号139期号:45页码:16235-16247
摘要Conventionally, ceramics-based materials, fabricated by high-temperature solid-phase reaction and sintering, are preferred as bone scaffolds in hard-tissue engineering because of their tunable biocompatibility and mechanical properties. However, their possible biomedical applications have rarely been considered, especially the cancer phototherapeutic applications in both the first and second near-infrared light (NIR-I and NIR-II) biowindows. In this work, we explore, for the first time as far as we know, a novel kind of 2D niobium carbide (Nb2C), MXene, with highly efficient in vivo photothermal ablation of mouse tumor xenografts in both NIR-I and NIR-II windows. The 2D Nb2C nanosheets (NSs) were fabricated by a facile and scalable two-step liquid exfoliation method combining stepwise delamination and intercalation procedures. The ultrathin, lateral-nanosized Nb2C NSs exhibited extraordinarily high photothermal conversion efficiency (36.4% at NIR-I and 45.65% at NIR-II), as well as high photothermal stability. The Nb2C NSs intrinsically feature unique enzyme-responsive biodegradability to human myeloperoxidase, low phototoxicity, and high biocompatibility. Especially, these surface-engineered Nb2C NSs present highly efficient in vivo photothermal ablation and eradication of tumor in both NIR-I and NIR-II biowindows. This work significantly broadens the application prospects of 2D MXenes by rationally designing their compositions and exploring related physiochemical properties, especially on phototherapy of cancer. © 2017 American Chemical Society.
DOI10.1021/jacs.7b07818
EI入藏号20174704425759
EI主题词Niobium compounds
EI分类号461 Bioengineering and Biology - 641.2 Heat Transfer - 801.2 Biochemistry - 804.2 Inorganic Compounds
引用统计
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25776
专题中国科学院上海硅酸盐研究所
作者单位1.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.University of Chinese Academy of Sciences, Beijing; 100049, China
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GB/T 7714
Lin, Han,Gao, Shanshan,Dai, Chen,et al. A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows[J]. Journal of the American Chemical Society,2017,139(45):16235-16247.
APA Lin, Han,Gao, Shanshan,Dai, Chen,Chen, Yu,&Shi, Jianlin.(2017).A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows.Journal of the American Chemical Society,139(45),16235-16247.
MLA Lin, Han,et al."A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows".Journal of the American Chemical Society 139.45(2017):16235-16247.
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