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Fabrication of novel magnesium-matrix composites and their mechanical properties prior to and during in vitro degradation
Dezfuli, Sina Naddaf1; Leeflang, Sander1; Huan, Zhiguang2; Chang, Jiang2; Zhou, Jie1
2017
Source PublicationJournal of the Mechanical Behavior of Biomedical Materials
ISSN17516161
Volume67Pages:74-86
AbstractIn our previous study, we developed Mg-matrix composites with bredigite as the reinforcing phase and achieved improved degradation resistance in comparison with Mg. However, the effects of materials processing method and process parameters on the mechanical behavior of the composites before and during degradation were still unknown. This research was aimed at determining the mechanical properties of Mg-bredigite composites prior to and during degradation. It was found that by optimizing the process parameters of Pressure Assisted Sintering (PAS), low-porosity Mg-bredigite composites with strong interfaces between homogeneously distributed bredigite particles and the Mg matrix could be fabricated. By reinforcing Mg with 20 vol% bredigite particles, the ultimate compressive strength and ductility of Mg increased by 67% and 111%, respectively. The in vitro degradation rate of the Mg-20% bredigite composite in a cell culture medium was 24 times lower than that of monolithic Mg. As a result of retarded degradation, the mechanical properties of the composite after 12 days of immersion in the cell culture medium were comparable to those of cortical bone. The encouraging results of this research warrant further investigations on the in vivo degradation behavior and mechanical properties of the composites. © 2016 Elsevier Ltd
DOI10.1016/j.jmbbm.2016.10.010
EI Accession Number20165103140342
EI KeywordsBiomechanics
EI Classification Number461.3 Biomechanics, Bionics and Biomimetics - 461.8 Biotechnology - 542.2 Magnesium and Alloys - 802.2 Chemical Reactions - 951 Materials Science
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Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25751
Collection中国科学院上海硅酸盐研究所
Corresponding AuthorDezfuli, Sina Naddaf
Affiliation1.Department of Biomechanical Engineering, Delft University of Technology, Delft; 2628 CD, Netherlands;
2.Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China
Recommended Citation
GB/T 7714
Dezfuli, Sina Naddaf,Leeflang, Sander,Huan, Zhiguang,et al. Fabrication of novel magnesium-matrix composites and their mechanical properties prior to and during in vitro degradation[J]. Journal of the Mechanical Behavior of Biomedical Materials,2017,67:74-86.
APA Dezfuli, Sina Naddaf,Leeflang, Sander,Huan, Zhiguang,Chang, Jiang,&Zhou, Jie.(2017).Fabrication of novel magnesium-matrix composites and their mechanical properties prior to and during in vitro degradation.Journal of the Mechanical Behavior of Biomedical Materials,67,74-86.
MLA Dezfuli, Sina Naddaf,et al."Fabrication of novel magnesium-matrix composites and their mechanical properties prior to and during in vitro degradation".Journal of the Mechanical Behavior of Biomedical Materials 67(2017):74-86.
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