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Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer
Jin, Yingying1; Ni, Dalong2; Zhang, Jiawen1; Han, Fang1; Wang, Jing1; Gao, Lu1; Zhang, Hua1; Liu, Yanyan2; Cui, Zhaowen2; Yao, Zhenwei1; Feng, Xiaoyuan1; Bu, Wenbo2,3
2017
Source PublicationParticle and Particle Systems Characterization
ISSN09340866
Volume34Issue:3
AbstractColon cancer (CC) is one of the most common intestinal malignancies and is difficult to detect in its early stage by magnetic resonance imaging (MRI) with currently used contrast agents (CAs). The development of targeted CAs contributes to the early diagnosis of CC and thereby enables early intervention and timely therapy. Considering the outstanding performance of upconversion nanoprobes (UCNPs) in high-performance MR and fluorescence imaging, a new type of nanoprobes with considerably enhanced imaging performance is developed herein. Carcinoembryonic antigen (CEA) antibody is conjugated onto the surface of UCNPs to achieve the targeted imaging of early CC tumors, which overexpress CEA. Both toxicity tests and histological/hematological examinations demonstrate the excellent biocompatibility of these CC-targeting nanoprobes, which possess great potential for clinical application in the early diagnosis of CC. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI10.1002/ppsc.201600393
EI Accession Number20170803374071
EI KeywordsMagnetic resonance imaging
EI Classification Number461.6 Medicine and Pharmacology - 461.9.1 Immunology - 701.2 Magnetism: Basic Concepts and Phenomena - 761 Nanotechnology - 931.1 Mechanics - 933 Solid State Physics
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25738
Collection中国科学院上海硅酸盐研究所
Affiliation1.Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai; 200040, China;
2.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China;
3.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai; 200062, China
Recommended Citation
GB/T 7714
Jin, Yingying,Ni, Dalong,Zhang, Jiawen,et al. Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer[J]. Particle and Particle Systems Characterization,2017,34(3).
APA Jin, Yingying.,Ni, Dalong.,Zhang, Jiawen.,Han, Fang.,Wang, Jing.,...&Bu, Wenbo.(2017).Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer.Particle and Particle Systems Characterization,34(3).
MLA Jin, Yingying,et al."Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer".Particle and Particle Systems Characterization 34.3(2017).
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