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Enhanced anti-infective efficacy of zno nanoreservoirs through a combination of intrinsic anti-biofilm activity and reinforced innate defense
Wang, Jiaxing1; Zhou, Huaijuan2; Guo, Geyong1; Tan, Jiaqi1; Wang, Qiaojie1; Tang, Jin5; Liu, Wei1; Shen, Hao1; Li, Jinhua2,3,4; Zhang, Xianlong1
2017
Source PublicationACS Applied Materials and Interfaces
ISSN19448244
Volume9Issue:39Pages:33609-33623
AbstractThe increasing prevalence of implant-associated infections (IAIs) imposes a heavy burden on patients and medical providers. Bacterial biofilms are recalcitrant to antiseptic drugs and local immune defense and can attenuate host proinflammatory response to interfere with bacterial clearance. Zinc oxide nanoparticles (ZnO NPs) play a dual role in antibacterial and immunomodulatory activities but compromise the cytocompatibility because of their intracellular uptake. Here, ZnO NPs were immobilized on titanium to form homogeneous nanofilms (from discontinuous to continuous) through magnetron sputtering, and the possible antimicrobial activity and immunomodulatory effect of nano-ZnO films were investigated. Nano-ZnO films were found to prohibit sessile bacteria more than planktonic bacteria in vitro, and the antibacterial effect occurred in a dose-dependent manner. Using a novel mouse soft tissue IAI model, the in vivo results revealed that nano-ZnO films possessed outstanding antimicrobial efficacy, which could not be ascribed solely to the intrinsic anti-infective activity of nano-ZnO films observed in vitro. Macrophages and polymorphonuclear leukocytes (PMNs), two important factors in innate immune response, were cocultured with nano-ZnO and bacteria/lipopolysaccharide in vitro, and the nano-ZnO films could enhance the antimicrobial efficacy of macrophages and PMNs through promoting phagocytosis and secretion of inflammatory cytokines. This study provides insights into the anti-infective activity and mechanism of ZnO and consolidates the theoretical basis for future clinical applications of ZnO. © 2017 American Chemical Society.
DOI10.1021/acsami.7b08864
EI Accession Number20174504372532
EI KeywordsZinc oxide
EI Classification Number461.9 Biology - 461.9.1 Immunology - 462.5 Biomaterials (including synthetics) - 723 Computer Software, Data Handling and Applications - 761 Nanotechnology - 804.2 Inorganic Compounds - 933 Solid State Physics
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25714
Collection中国科学院上海硅酸盐研究所
Affiliation1.Department of Orthopaedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai; 200233, China;
2.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
3.Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong; 999077, Hong Kong;
4.University of Chinese Academy of Sciences, Beijing; 100049, China;
5.Department of Clinical Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai; 200233, China
Recommended Citation
GB/T 7714
Wang, Jiaxing,Zhou, Huaijuan,Guo, Geyong,et al. Enhanced anti-infective efficacy of zno nanoreservoirs through a combination of intrinsic anti-biofilm activity and reinforced innate defense[J]. ACS Applied Materials and Interfaces,2017,9(39):33609-33623.
APA Wang, Jiaxing.,Zhou, Huaijuan.,Guo, Geyong.,Tan, Jiaqi.,Wang, Qiaojie.,...&Zhang, Xianlong.(2017).Enhanced anti-infective efficacy of zno nanoreservoirs through a combination of intrinsic anti-biofilm activity and reinforced innate defense.ACS Applied Materials and Interfaces,9(39),33609-33623.
MLA Wang, Jiaxing,et al."Enhanced anti-infective efficacy of zno nanoreservoirs through a combination of intrinsic anti-biofilm activity and reinforced innate defense".ACS Applied Materials and Interfaces 9.39(2017):33609-33623.
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