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Si-doped porous TiO2coatings enhanced in vitro angiogenic behavior of human umbilical vein endothelial cells
Ding, Zhihong1,2; Qiao, Yuqin3; Peng, Feng3; Xia, Chao3; Qian, Shi3; Wang, Tao1; Sun, Junying1; Liu, Xuanyong3
2017
Source PublicationColloids and Surfaces B: Biointerfaces
ISSN09277765
Volume159Pages:493-500
AbstractRecent evidence demonstrates that vessel involvement is crucial in various bone remodeling situations, indicating that blood vessel formation within or surrounding the implant is essential for establishment of rigid implant fixation. In this work, the ability of the silicon-doped porous TiO2coatings fabricated via plasma electrolyte oxidation method (PEO) to enhance the angiogenic potential of human umbilical vein endothelial cells (HUVECs) were investigated. The cellular responses of HUVECs on the silicon-doped porous TiO2coatings were studied through cell proliferation, vascular endothelial growth factor (VEGF) secretion, and angiogenic-associated gene (VEGF, HIF-1α and HGF) expression analysis. The results show that small amount of silicon significantly enhanced angiogenic activity of HUVECs, while larger amount of silicon appears excessive. Hence, the silicon-doped TiO2coating offers a potential solution to improve bone vascularization to achieve efficient osseointegration and restoration of function after implantation. © 2017 Elsevier B.V.
DOI10.1016/j.colsurfb.2017.08.010
EI Accession Number20173504086513
EI KeywordsEndothelial cells
EI Classification Number461 Bioengineering and Biology - 549.3 Nonferrous Metals and Alloys excluding Alkali and Alkaline Earth Metals - 702 Electric Batteries and Fuel Cells - 803 Chemical Agents and Basic Industrial Chemicals - 804 Chemical Products Generally - 804.2 Inorganic Compounds - 813.2 Coating Materials - 971 Social Sciences
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25689
Collection中国科学院上海硅酸盐研究所
Affiliation1.Department of Orthopedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou; Jiangsu; 215006, China;
2.Department of Orthopedics Shanghai Pudong New Area Gongli Hospital, Shanghai; 200135, China;
3.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China
Recommended Citation
GB/T 7714
Ding, Zhihong,Qiao, Yuqin,Peng, Feng,et al. Si-doped porous TiO2coatings enhanced in vitro angiogenic behavior of human umbilical vein endothelial cells[J]. Colloids and Surfaces B: Biointerfaces,2017,159:493-500.
APA Ding, Zhihong.,Qiao, Yuqin.,Peng, Feng.,Xia, Chao.,Qian, Shi.,...&Liu, Xuanyong.(2017).Si-doped porous TiO2coatings enhanced in vitro angiogenic behavior of human umbilical vein endothelial cells.Colloids and Surfaces B: Biointerfaces,159,493-500.
MLA Ding, Zhihong,et al."Si-doped porous TiO2coatings enhanced in vitro angiogenic behavior of human umbilical vein endothelial cells".Colloids and Surfaces B: Biointerfaces 159(2017):493-500.
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