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Bioglass promotes wound healing through modulating the paracrine effects between macrophages and repairing cells
Dong, Xin1; Chang, Jiang1,2; Li, Haiyan1
2017
Source PublicationJournal of Materials Chemistry B
ISSN20507518
Volume5Issue:26Pages:5240-5250
AbstractIt has been well accepted that inflammation is a critical stage in the wound healing process and the paracrine effects between macrophages and repairing cells play critical roles in wound healing. Although bioactive glass (BG), such as 45S5 bioglass, has been reported to be able to accelerate skin regeneration through enhancing angiogenesis and collagen deposition in the proliferation stage of the wound healing process, the effects of BG on the inflammation responses of wound healing have rarely been studied. To further elucidate the mechanism of BG enhancing wound healing, in this study, the effects of BG on the phenotype switch of macrophages and paracrine effects between the macrophages and repairing cells in wound healing were investigated. The results showed that BG ionic products activated macrophages towards the M2 phenotype and stimulated macrophages to express more anti-inflammatory and angiogenic growth factors compared to control medium. Conditioned medium of macrophages cultured with BG accelerated the migration of endothelial cells and fibroblasts, thus increasing the capillary-like network formation of endothelial cells and the extracellular matrix protein deposition of fibroblasts. When BG powders were applied to full-thickness excisional wounds of rats, the wound closure was accelerated by BG as compared to the control group. Reduced inflammation during initial stages of healing was observed, which was evidenced by fewer neutrophils and more M2 macrophages in the wound sites treated with BG compared to those without any treatment. All these results indicate that modulating the inflammatory response is one of the critical mechanisms for BG enhancing wound healing. © 2017 The Royal Society of Chemistry.
DOI10.1039/c7tb01211j
EI Accession Number20172803932413
EI KeywordsEndothelial cells
EI Classification Number461 Bioengineering and Biology - 462.5 Biomaterials (including synthetics) - 802.3 Chemical Operations - 913.5 Maintenance
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Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25678
Collection中国科学院上海硅酸盐研究所
Affiliation1.Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai; 200030, China;
2.State Key Laboratory of Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China
Recommended Citation
GB/T 7714
Dong, Xin,Chang, Jiang,Li, Haiyan. Bioglass promotes wound healing through modulating the paracrine effects between macrophages and repairing cells[J]. Journal of Materials Chemistry B,2017,5(26):5240-5250.
APA Dong, Xin,Chang, Jiang,&Li, Haiyan.(2017).Bioglass promotes wound healing through modulating the paracrine effects between macrophages and repairing cells.Journal of Materials Chemistry B,5(26),5240-5250.
MLA Dong, Xin,et al."Bioglass promotes wound healing through modulating the paracrine effects between macrophages and repairing cells".Journal of Materials Chemistry B 5.26(2017):5240-5250.
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