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Butyrate-inserted Ni–Ti layered double hydroxide film for H2O2-mediated tumor and bacteria killing
Wang, Donghui1,2; Peng, Feng1,2; Li, Jinhua1,2; Qiao, Yuqin1; Li, Qianwen1,2; Liu, Xuanyong1
2017
Source PublicationMaterials Today
ISSN13697021
Volume20Issue:5Pages:238-257
AbstractThe selective tumor- and bacteria-killing property is promising for biomedical implants in directly contact with tumor tissue but still presents a considerable challenge. In this study, a butyrate-inserted Ni–Ti layered double hydroxide film (LDH/Butyrate) is prepared on the surface of nitinol alloy via a simple hydrothermal treatment. The prepared film can selectively inhibit tumor growth and metastasis and bacterial infection by taking advantage of the overproduced H2O2in tumor and infection microenvironments: the pro-tumor and pro-infection molecule H2O2can be consumed by LDH/Butyrate, and cytotoxic butyrate inserted in LDH/Butyrate is subsequently exchanged out. Such a novel endogenous stimuli-responsive platform is expected to prevent tumor overgrowth, metastasis and bacterial infection and will find a promising application in the design of localized drug-eluting systems. © 2017 Elsevier Ltd
DOI10.1016/j.mattod.2017.05.001
EI Accession Number20172903952516
EI KeywordsTumors
EI Classification Number461.2 Biological Materials and Tissue Engineering - 461.6 Medicine and Pharmacology
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25658
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.University of Chinese Academy of Sciences, Beijing; 100049, China
Recommended Citation
GB/T 7714
Wang, Donghui,Peng, Feng,Li, Jinhua,等. Butyrate-inserted Ni–Ti layered double hydroxide film for H2O2-mediated tumor and bacteria killing[J]. Materials Today,2017,20(5):238-257.
APA Wang, Donghui,Peng, Feng,Li, Jinhua,Qiao, Yuqin,Li, Qianwen,&Liu, Xuanyong.(2017).Butyrate-inserted Ni–Ti layered double hydroxide film for H2O2-mediated tumor and bacteria killing.Materials Today,20(5),238-257.
MLA Wang, Donghui,et al."Butyrate-inserted Ni–Ti layered double hydroxide film for H2O2-mediated tumor and bacteria killing".Materials Today 20.5(2017):238-257.
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