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Near infrared-assisted Fenton reaction for tumor-specific and mitochondrial DNA-targeted photochemotherapy
Hu, Ping1; Wu, Tong3; Fan, Wenpei1; Chen, Lei4; Liu, Yanyan1; Ni, Dalong2; Bu, Wenbo2; Shi, Jianlin1
2017
Source PublicationBiomaterials
ISSN01429612
Volume141Pages:86-95
AbstractThe strong dependence on oxygen level, low ultraviolet/visible (UV/vis) light penetration depth and the extremely short lifetime of reactive oxygen species (ROS) are the major challenges of photodynamic therapy (PDT) for tumors. Fenton reaction can produce abundant ROS such as reactive hydroxyl radicals ([rad]OH) with significantly higher oxidation performance than singlet oxygen (1O2), which, however, has been rarely used in biomedical fields due to strict reaction conditions (favorably in pH range of 3–4, mostly under UV/vis light catalysis). Herein we propose and demonstrate a photochemotherapy (PCT) strategy of cancer therapy using near-infrared (NIR)-assisted tumor-specific Fenton reactions. NIR light-upconverted UV/vis light by upconversion nanoparticles (UCNPs) catalyze the intra-mitochondrial Fenton reaction between the delivered Fe2+and H2O2species over-expressed in cancer cell's mitochondria to in-situ kill the cancer cells. The intra-mitochondrial ROS generation of enabled by directly targeting the mitochondrial DNA (mtDNA) helix minimized the distance between the ROS and mtDNA molecules, thus the present PCT strategy showed much enhanced and tumor-specific therapeutic efficacy, as demonstrated by the intratumoral-accelerated [rad]OH burst and elevated cytotoxicity. Following the direct intratumoral injection, the PCT revealed marked tumor regression effect in vivo. This constructed PCT-agent is the first paradigm of NIR-upconversion catalyzed intra-mitochondrial Fenton reaction in response to tumoral microenvironment, establishing a novel photochemotherapy strategy for efficient cancer therapy. © 2017
DOI10.1016/j.biomaterials.2017.06.035
EI Accession Number20172703876029
EI KeywordsOxidation
EI Classification Number461.2 Biological Materials and Tissue Engineering - 461.6 Medicine and Pharmacology - 802.2 Chemical Reactions - 804 Chemical Products Generally
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Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25656
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai; 200062, China;
3.Department of Materials Science and Engineering, Stanford University, Stanford; CA; 94305, United States;
4.Department of Chemistry and Laboratory of Advanced Materials, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai; 200433, China
Recommended Citation
GB/T 7714
Hu, Ping,Wu, Tong,Fan, Wenpei,et al. Near infrared-assisted Fenton reaction for tumor-specific and mitochondrial DNA-targeted photochemotherapy[J]. Biomaterials,2017,141:86-95.
APA Hu, Ping.,Wu, Tong.,Fan, Wenpei.,Chen, Lei.,Liu, Yanyan.,...&Shi, Jianlin.(2017).Near infrared-assisted Fenton reaction for tumor-specific and mitochondrial DNA-targeted photochemotherapy.Biomaterials,141,86-95.
MLA Hu, Ping,et al."Near infrared-assisted Fenton reaction for tumor-specific and mitochondrial DNA-targeted photochemotherapy".Biomaterials 141(2017):86-95.
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