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Layer-Number Dependent Antibacterial and Osteogenic Behaviors of Graphene Oxide Electrophoretic Deposited on Titanium
Qiu, Jiajun1,3; Geng, Hao1,3; Wang, Donghui1,3; Qian, Shi1; Zhu, Hongqin1; Qiao, Yuqin1; Qian, Wenhao2; Liu, Xuanyong1
2017
发表期刊ACS Applied Materials and Interfaces
ISSN19448244
卷号9期号:14页码:12253-12263
摘要Graphene oxide has attracted widespread attention in the biomedical fields due to its excellent biocompatibility. Herein we investigated the layer-number dependent antibacterial and osteogenic behaviors of graphene oxide in biointerfaces. Graphene oxide with different layer numbers was deposited on the titanium surfaces by cathodal electrophoretic deposition with varied deposition voltages. The initial cell adhesion and spreading, cell proliferation, and osteogenic differentiation were observed from all the samples using rat bone mesenchymal stem cells. Both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus were used to investigate the antibacterial effect of the modified titanium surfaces. Cocultures of human gingival fibroblasts (HGF) cells with Escherichia coli and Staphylococcus aureus were conducted to simulate the conditions of the clinical practice. The results show that the titanium surfaces with graphene oxide exhibited excellent antibacterial and osteogenic effects. Increasing the layer-number of graphene oxide resulted in the augment of reactive oxygen species levels and the wrinkling, which led to the antibacterial and osteogenic effects, respectively. Compared to pure titanium surface in the cells-bacteria coculture process, the modified titanium surfaces with graphene oxide exhibited higher surface coverage percentage of cells. © 2017 American Chemical Society.
DOI10.1021/acsami.7b00314
EI入藏号20171603580177
EI主题词Graphene
EI分类号461 Bioengineering and Biology - 542.3 Titanium and Alloys - 701.1 Electricity: Basic Concepts and Phenomena - 761 Nanotechnology - 802.3 Chemical Operations - 804 Chemical Products Generally - 804.2 Inorganic Compounds
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25651
专题中国科学院上海硅酸盐研究所
作者单位1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.Shanghai Xuhui District Dental Center, Shanghai; 200032, China;
3.University of Chinese Academy of Sciences, Beijing; 100049, China
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GB/T 7714
Qiu, Jiajun,Geng, Hao,Wang, Donghui,et al. Layer-Number Dependent Antibacterial and Osteogenic Behaviors of Graphene Oxide Electrophoretic Deposited on Titanium[J]. ACS Applied Materials and Interfaces,2017,9(14):12253-12263.
APA Qiu, Jiajun.,Geng, Hao.,Wang, Donghui.,Qian, Shi.,Zhu, Hongqin.,...&Liu, Xuanyong.(2017).Layer-Number Dependent Antibacterial and Osteogenic Behaviors of Graphene Oxide Electrophoretic Deposited on Titanium.ACS Applied Materials and Interfaces,9(14),12253-12263.
MLA Qiu, Jiajun,et al."Layer-Number Dependent Antibacterial and Osteogenic Behaviors of Graphene Oxide Electrophoretic Deposited on Titanium".ACS Applied Materials and Interfaces 9.14(2017):12253-12263.
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