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Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion
Lin, Han1,2; Wang, Xingang1; Yu, Luodan1,2; Chen, Yu1; Shi, Jianlin1
2017
Source PublicationNano Letters
ISSN15306984
Volume17Issue:1Pages:384-391
AbstractCeramic biomaterials have been investigated for several decades, but their potential biomedical applications in cancer therapy have been paid much less attentions, mainly due to their lack of related material functionality for combating the cancer. In this work, we report, for the first time, that MAX ceramic biomaterials exhibit the unique functionality for the photothermal ablation of cancer upon being exfoliated into ultrathin nanosheets within atomic thickness (MXene). As a paradigm, biocompatible Ti3C2nanosheets (MXenes) were successfully synthesized based on a two-step exfoliation strategy of MAX phase Ti3AlC2by the combined HF etching and TPAOH intercalation. Especially, the high photothermalconversion efficiency and in vitro/in vivo photothermal ablation of tumor of Ti3C2nanosheets (MXenes) were revealed and demonstrated, not only in the intravenous administration of soybean phospholipid modified Ti3C2nanosheets but also in the localized intratumoral implantation of a phase-changeable PLGA/Ti3C2organic-inorganic hybrid. This work promises the great potential of Ti3C2nanosheets (MXenes) as a novel ceramic photothermal agent used for cancer therapy and may arouse much interest in exploring MXene-based ceramic biomaterials to benefit the biomedical applications. © 2016 American Chemical Society.
DOI10.1021/acs.nanolett.6b04339
EI Accession Number20171303513005
EI KeywordsTitanium compounds
EI Classification Number461 Bioengineering and Biology - 641.2 Heat Transfer - 761 Nanotechnology - 804.1 Organic Compounds - 812.1 Ceramics - 933 Solid State Physics
Citation statistics
Cited Times:151[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25638
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.University of Chinese Academy of Sciences, Beijing; 100049, China
Recommended Citation
GB/T 7714
Lin, Han,Wang, Xingang,Yu, Luodan,et al. Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion[J]. Nano Letters,2017,17(1):384-391.
APA Lin, Han,Wang, Xingang,Yu, Luodan,Chen, Yu,&Shi, Jianlin.(2017).Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion.Nano Letters,17(1),384-391.
MLA Lin, Han,et al."Two-Dimensional Ultrathin MXene Ceramic Nanosheets for Photothermal Conversion".Nano Letters 17.1(2017):384-391.
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