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Material chemistry of graphene oxide-based nanocomposites for theranostic nanomedicine
Zhou, Yang1; Jing, Xiangxiang2; Chen, Yu3
2017
发表期刊Journal of Materials Chemistry B
ISSN20507518
卷号5期号:32页码:6451-6470
摘要The promising biomedical applications of graphene oxide (GO) have quickly catalyzed a generation of various GO-based functional composites with desirable nanostructures and composites to satisfy the specific biomedical applications of GO-based nanosystems. This comprehensive review summarizes and discusses the very recent developments in rational design, chemical fabrication and versatile biomedical applications of GO-based functional composites, including metal oxide-GO, metal-GO, fluorescent nanoparticles-GO, silica-GO, polymer-GO and other specific GO-based composite nanosystems. The integration of multi-components with GO is also discussed. Their versatile theranostic applications include diagnostic imaging-guided therapy (photothermal therapy, photodynamic therapy and chemotherapy), biosensing-based tumor detection, and synergistic therapy. The biocompatibility and biosafety of these promising GO-based nanocomposites are also briefly mentioned. Finally, the unresolved critical issues and challenges facing the design/fabrication/application of these unique GO-based functional nanocomposites are proposed to further promote their clinical translation. The unique multi-composition, nanostructure and unique theranostic performance of GO-based composites are highly expected to pave a new way for the development of highly efficient theranostic protocols/approaches for precise personalized biomedicine to benefit human health. © 2017 The Royal Society of Chemistry.
DOI10.1039/c7tb00680b
EI入藏号20173404056256
EI主题词Photodynamic therapy
EI分类号461.6 Medicine and Pharmacology - 461.9.1 Immunology - 761 Nanotechnology - 815.1 Polymeric Materials
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文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25626
专题中国科学院上海硅酸盐研究所
作者单位1.Department of Ultrasound, Third People's Hospital of Chengdu City, Affiliated Hospital of Southwest, Jiaotong University, Chengdu; 610031, China;
2.Department of Ultrasound, Hainan General Hospital, Haikou; 570311, China;
3.State Key Lab of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China
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Zhou, Yang,Jing, Xiangxiang,Chen, Yu. Material chemistry of graphene oxide-based nanocomposites for theranostic nanomedicine[J]. Journal of Materials Chemistry B,2017,5(32):6451-6470.
APA Zhou, Yang,Jing, Xiangxiang,&Chen, Yu.(2017).Material chemistry of graphene oxide-based nanocomposites for theranostic nanomedicine.Journal of Materials Chemistry B,5(32),6451-6470.
MLA Zhou, Yang,et al."Material chemistry of graphene oxide-based nanocomposites for theranostic nanomedicine".Journal of Materials Chemistry B 5.32(2017):6451-6470.
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