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Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications
Ma, Ming1; Yan, Yanhong2; Qi, Chao1; Qi, Shengcai3; Chern, Shixiong1; Shang, Guangwei3; Wang, Raorao3; Chen, Hangrong1
2017
Source PublicationScience China Materials
ISSN20958226
Volume60Issue:6Pages:516-528
AbstractBiomedical applications of porous calcium carbonate (CaCO3) microspheres have been mainly restricted by their aqueous instability and low remineralization rate. To overcome these obstacles, a novel symmetry-breaking assembled porous calcite microsphere (PCMS) was constructed in an ethanol/water mixed system using a two-step vapor-diffusion/aging crystallization strategy. In contrast to the conventional additive-induced crystallization method, the present strategy was performed under mild conditions and was free from any foreign additives, thus avoiding the potential contamination of the final product. Meanwhile, the prepared PCMSs were characterized by their highly uniform spherical morphology and large open pores, which are favorable for large protein delivery. An antimicrobial study of immunoglobulin Y (IgY)-loaded PCMSs revealed excellent antimicrobial activity against Streptococcus mutans. More importantly, they showed surprisingly rapid transformation to bone minerals in physiological medium. Evaluation of the in vitro efficacy of PCMSs in dentinal tubule occlusion demonstrated their powerful potential to serve as a catalyst in the repair of dental hard tissue. Therefore, the developed PCMSs show great promise as multifunctional biomaterials for dental treatment applications. © 2017, Science China Press and Springer-Verlag GmbH Germany.
DOI10.1007/s40843-017-9038-5
EI Accession Number20174804475654
EI KeywordsMicrospheres
EI Classification Number461.9 Biology - 803 Chemical Agents and Basic Industrial Chemicals - 804 Chemical Products Generally
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25618
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Lab of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Pediatric Dentistry, School of Stomatology, Tongji University, Shanghai; 200072, China;
3.Department of Stomatology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai; 200072, China
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GB/T 7714
Ma, Ming,Yan, Yanhong,Qi, Chao,et al. Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications[J]. Science China Materials,2017,60(6):516-528.
APA Ma, Ming.,Yan, Yanhong.,Qi, Chao.,Qi, Shengcai.,Chern, Shixiong.,...&Chen, Hangrong.(2017).Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications.Science China Materials,60(6),516-528.
MLA Ma, Ming,et al."Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications".Science China Materials 60.6(2017):516-528.
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