SIC OpenIR
Materials Chemistry of Nanoultrasonic Biomedicine
Tang, Hailin1; Zheng, Yuanyi3; Chen, Yu2
2017
发表期刊Advanced Materials
ISSN09359648
卷号29期号:10
摘要As a special cross-disciplinary research frontier, nanoultrasonic biomedicine refers to the design and synthesis of nanomaterials to solve some critical issues of ultrasound (US)-based biomedicine. The concept of nanoultrasonic biomedicine can also overcome the drawbacks of traditional microbubbles and promote the generation of novel US-based contrast agents or synergistic agents for US theranostics. Here, we discuss the recent developments of material chemistry in advancing the nanoultrasonic biomedicine for diverse US-based bio-applications. We initially introduce the design principles of novel nanoplatforms for serving the nanoultrasonic biomedicine, from the viewpoint of synthetic material chemistry. Based on these principles and diverse US-based bio-application backgrounds, the representative proof-of-concept paradigms on this topic are clarified in detail, including nanodroplet vaporization for intelligent/responsive US imaging, multifunctional nano-contrast agents for US-based multi-modality imaging, activatable synergistic agents for US-based therapy, US-triggered on-demand drug releasing, US-enhanced gene transfection, US-based synergistic therapy on combating the cancer and potential toxicity issue of screening various nanosystems suitable for nanoultrasonic biomedicine. It is highly expected that this novel nanoultrasonic biomedicine and corresponding high performance in US imaging and therapy can significantly promote the generation of new sub-discipline of US-based biomedicine by rationally integrating material chemistry and theranostic nanomedicine with clinical US-based biomedicine. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
DOI10.1002/adma.201604105
EI入藏号20165203189048
EI主题词Gene therapy
EI分类号461.8.1 Genetic Engineering - 751 Acoustics, Noise. Sound - 761 Nanotechnology
引用统计
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25607
专题中国科学院上海硅酸盐研究所
作者单位1.Department of Diagnostic Ultrasound, Tongde Hospital of Zhejiang Province, Hangzhou; 310012, China;
2.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
3.Shanghai Institute of Ultrasound in Medicine, Shanghai Jiaotong University Affiliated, Shanghai Sixth People's Hospital, Shanghai; 200233, China
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GB/T 7714
Tang, Hailin,Zheng, Yuanyi,Chen, Yu. Materials Chemistry of Nanoultrasonic Biomedicine[J]. Advanced Materials,2017,29(10).
APA Tang, Hailin,Zheng, Yuanyi,&Chen, Yu.(2017).Materials Chemistry of Nanoultrasonic Biomedicine.Advanced Materials,29(10).
MLA Tang, Hailin,et al."Materials Chemistry of Nanoultrasonic Biomedicine".Advanced Materials 29.10(2017).
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