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3D-printed bioceramic scaffolds with antibacterial and osteogenic activity
Zhang, Yongliang1,2; Zhai, Dong1; Xu, Mengchi1; Yao, Qingqiang3; Zhu, Huiying1; Chang, Jiang1; Wu, Chengtie1
2017
发表期刊Biofabrication
ISSN17585082
卷号9期号:2
摘要Bacterial infection poses a significant risk with the wide application of bone graft materials. Designing bone grafts with good antibacterial performance and excellent bone-forming activity is of particular significance for bone tissue engineering. In our study, a 3D printing method was used to prepare β-tricalcium phosphate (β-TCP) bioceramic scaffolds. Silver (Ag) nanoparticles were uniformly dispersed on graphene oxide (GO) to form a homogeneous nanocomposite (named Ag@GO) with different Ag-to-graphene oxide mass ratios, with this being synthesized via the liquid chemical reduction approach. Ag@GO nanocomposites were successfully modified on the β-TCP scaffolds by a simple soaking method to achieve bifunctional biomaterials with antibacterial and osteogenic activity. The prepared scaffolds possessed a connected network with triangle pore morphology and the surfaces of the β-TCP scaffolds were uniformly modified by the Ag@GO nanocomposite layers. The Ag content in the scaffolds was controlled by changing the coating times and concentration of the Ag@GO nanocomposites. The antibacterial activity of the scaffolds was assessed with Gram-negative bacteria (Escherichia coli, E. coli). The results demonstrated that the scaffolds with Ag@GO nanocomposites presented excellent antibacterial activity. In addition, the scaffolds coated with Ag@GO nanocomposites conspicuously accelerated the osteogenic differentiation of rabbit bone marrow stromal cells by improving their alkaline phosphatase activity and bone-related gene expression (osteopontin, runt-related transcription factor 2, osteocalcin and bone sialoprotein). This study demonstrates that bifunctional scaffolds with a combination of antibacterial and osteogenic activity can be achieved for the reconstruction of large-bone defects while preventing or treating infections. © 2017 IOP Publishing Ltd.
DOI10.1088/1758-5090/aa6ed6
EI入藏号20172803931107
EI主题词Scaffolds (biology)
EI分类号461 Bioengineering and Biology - 462.5 Biomaterials (including synthetics) - 723 Computer Software, Data Handling and Applications - 745.1.1 Printing Equipment - 761 Nanotechnology - 801.1 Chemistry, General - 802.2 Chemical Reactions - 804 Chemical Products Generally - 933 Solid State Physics
引用统计
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25597
专题中国科学院上海硅酸盐研究所
通讯作者Zhang, Yongliang
作者单位1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.Shanghai Engineering Research Center of Single Crystal Silicon Carbide, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
3.Department of Orthopaedic Surgery, Digital Medicine Institute, Nanjing Medical University, Nanjing Hospital, 68 Changle Road, Nanjing; 210006, China
推荐引用方式
GB/T 7714
Zhang, Yongliang,Zhai, Dong,Xu, Mengchi,et al. 3D-printed bioceramic scaffolds with antibacterial and osteogenic activity[J]. Biofabrication,2017,9(2).
APA Zhang, Yongliang.,Zhai, Dong.,Xu, Mengchi.,Yao, Qingqiang.,Zhu, Huiying.,...&Wu, Chengtie.(2017).3D-printed bioceramic scaffolds with antibacterial and osteogenic activity.Biofabrication,9(2).
MLA Zhang, Yongliang,et al."3D-printed bioceramic scaffolds with antibacterial and osteogenic activity".Biofabrication 9.2(2017).
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