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Insights into the unique functionality of inorganic micro/nanoparticles for versatile ultrasound theranostics
Qian, Xiaoqin1; Han, Xiaoxia3; Chen, Yu2
2017
Source PublicationBiomaterials
ISSN01429612
Volume142Pages:13-30
AbstractThe clinical ultrasound (US)-based theranostic biomedicine suffers from the critical issue that traditional microbubbles (MBs) have lots of drawbacks such as low stability, large particle size, difficult structural control, etc. The unique composition, structure and functionality of inorganic micro/nanoplatforms have shown their great prospect for solving these critical issues and drawbacks of traditional organic MBs. This review summarizes and discusses the state-of-art development on exploring inorganic micro/nanoparticles for versatile US-based biomedical applications, ranging from US imaging, photoacoustic imaging, sonodynamic therapy, high intensity-focused US ablation and US-triggered chemotherapy. These inorganic micro/nanoplatforms include silica-based particles, Au, carbon nanotubes, TiO2, manganese oxide, iron oxide, Prussian blue, inorganic gas-generating nanoparticles and their versatile composite micro/nanosystems. Especially, their unique structure/composition-functionality relationships and biocompatibility/biosafety in US-based theranostics have been discussed and revealed in detail. Their facing challenges and future developments are finally discussed to promote their further clinical translations. It is highly expected that these inorganic micro/nanoplatforms will enter the clinical stage to benefit the personalized theranostics biomedicine based on their unique functionalities and high performance as necessarily required in US-based theranostics. © 2017 Elsevier Ltd
DOI10.1016/j.biomaterials.2017.07.016
EI Accession Number20172903958173
EI KeywordsIron oxides
EI Classification Number408 Structural Design - 461.6 Medicine and Pharmacology - 461.9.1 Immunology - 753.1 Ultrasonic Waves - 761 Nanotechnology - 804 Chemical Products Generally - 804.2 Inorganic Compounds - 819.4 Fiber Products
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25566
Collection中国科学院上海硅酸盐研究所
Affiliation1.Department of Ultrasound, Affiliated People's Hospital of Jiangsu University, Zhenjiang; Jiangsu; 212002, China;
2.State Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
3.Institute of Ultrasound Imaging and Department of Ultrasound, Second Affiliated Hospital of Chongqing Medical University, Chongqing; 400010, China
Recommended Citation
GB/T 7714
Qian, Xiaoqin,Han, Xiaoxia,Chen, Yu. Insights into the unique functionality of inorganic micro/nanoparticles for versatile ultrasound theranostics[J]. Biomaterials,2017,142:13-30.
APA Qian, Xiaoqin,Han, Xiaoxia,&Chen, Yu.(2017).Insights into the unique functionality of inorganic micro/nanoparticles for versatile ultrasound theranostics.Biomaterials,142,13-30.
MLA Qian, Xiaoqin,et al."Insights into the unique functionality of inorganic micro/nanoparticles for versatile ultrasound theranostics".Biomaterials 142(2017):13-30.
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