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Multifunctional Hydrogels Prepared by Dual Ion Cross-Linking for Chronic Wound Healing
Li, Yonghui1; Han, Yan1; Wang, Xiaoya1; Peng, Jinliang2; Xu, Yuhong2; Chang, Jiang1
2017
发表期刊ACS Applied Materials and Interfaces
ISSN19448244
卷号9期号:19页码:16054-16062
摘要The creation of a moist environment and promotion of blood vessel formation are critical for wound healing. Sodium alginate (SA) hydrogel, which has good biocompatibility and is able to provide a moist environment, has been widely used as a wound dressing. However, it lacks antibacterial ability and bioactivities, which would facilitate chronic wound healing. On the basis of the gelation characteristics of SA and the bioactive hardystonite (HS) bioceramic, we designed a unique, bioactive, injectable composite hydrogel through double ion cross-linking, in which divalent ions, such as Ca2+and Zn2+function as cross-linkers; Zn2+also functions as an antibacterial component and as nutrition for wound healing, and Si ions play a key role in determining the bioactivity of the hydrogel. With the controlled release of divalent ions, such as Ca2+and Zn2+from HS, the gelation process of the composite hydrogel could be efficiently controlled. In addition, in vitro results reveal that the composite hydrogel stimulated proliferation and migration of both human dermal fibroblasts and human umbilical vein endothelial cells, and the in vivo results show that the wound-healing process is obviously enhanced, and the formation of epithelium and blood vessels are evidently advanced. This study indicates the potential of the SA/HS hydrogel as a multifunctional injectable wound dressing with the ability to inhibit bacterial growth and stimulate angiogenesis and wound healing. © 2017 American Chemical Society.
DOI10.1021/acsami.7b04801
EI入藏号20172203700909
EI主题词Hydrogels
EI分类号461 Bioengineering and Biology - 802.3 Chemical Operations - 804 Chemical Products Generally - 804.1 Organic Compounds
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.sic.ac.cn/handle/331005/25563
专题中国科学院上海硅酸盐研究所
作者单位1.Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China;
2.School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai; 200240, China
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GB/T 7714
Li, Yonghui,Han, Yan,Wang, Xiaoya,et al. Multifunctional Hydrogels Prepared by Dual Ion Cross-Linking for Chronic Wound Healing[J]. ACS Applied Materials and Interfaces,2017,9(19):16054-16062.
APA Li, Yonghui,Han, Yan,Wang, Xiaoya,Peng, Jinliang,Xu, Yuhong,&Chang, Jiang.(2017).Multifunctional Hydrogels Prepared by Dual Ion Cross-Linking for Chronic Wound Healing.ACS Applied Materials and Interfaces,9(19),16054-16062.
MLA Li, Yonghui,et al."Multifunctional Hydrogels Prepared by Dual Ion Cross-Linking for Chronic Wound Healing".ACS Applied Materials and Interfaces 9.19(2017):16054-16062.
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