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Multifunctional Hydrogels Prepared by Dual Ion Cross-Linking for Chronic Wound Healing
Li, Yonghui1; Han, Yan1; Wang, Xiaoya1; Peng, Jinliang2; Xu, Yuhong2; Chang, Jiang1
2017
Source PublicationACS Applied Materials and Interfaces
ISSN19448244
Volume9Issue:19Pages:16054-16062
AbstractThe creation of a moist environment and promotion of blood vessel formation are critical for wound healing. Sodium alginate (SA) hydrogel, which has good biocompatibility and is able to provide a moist environment, has been widely used as a wound dressing. However, it lacks antibacterial ability and bioactivities, which would facilitate chronic wound healing. On the basis of the gelation characteristics of SA and the bioactive hardystonite (HS) bioceramic, we designed a unique, bioactive, injectable composite hydrogel through double ion cross-linking, in which divalent ions, such as Ca2+and Zn2+function as cross-linkers; Zn2+also functions as an antibacterial component and as nutrition for wound healing, and Si ions play a key role in determining the bioactivity of the hydrogel. With the controlled release of divalent ions, such as Ca2+and Zn2+from HS, the gelation process of the composite hydrogel could be efficiently controlled. In addition, in vitro results reveal that the composite hydrogel stimulated proliferation and migration of both human dermal fibroblasts and human umbilical vein endothelial cells, and the in vivo results show that the wound-healing process is obviously enhanced, and the formation of epithelium and blood vessels are evidently advanced. This study indicates the potential of the SA/HS hydrogel as a multifunctional injectable wound dressing with the ability to inhibit bacterial growth and stimulate angiogenesis and wound healing. © 2017 American Chemical Society.
DOI10.1021/acsami.7b04801
EI Accession Number20172203700909
EI KeywordsHydrogels
EI Classification Number461 Bioengineering and Biology - 802.3 Chemical Operations - 804 Chemical Products Generally - 804.1 Organic Compounds
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Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25563
Collection中国科学院上海硅酸盐研究所
Affiliation1.Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai; 200050, China;
2.School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai; 200240, China
Recommended Citation
GB/T 7714
Li, Yonghui,Han, Yan,Wang, Xiaoya,et al. Multifunctional Hydrogels Prepared by Dual Ion Cross-Linking for Chronic Wound Healing[J]. ACS Applied Materials and Interfaces,2017,9(19):16054-16062.
APA Li, Yonghui,Han, Yan,Wang, Xiaoya,Peng, Jinliang,Xu, Yuhong,&Chang, Jiang.(2017).Multifunctional Hydrogels Prepared by Dual Ion Cross-Linking for Chronic Wound Healing.ACS Applied Materials and Interfaces,9(19),16054-16062.
MLA Li, Yonghui,et al."Multifunctional Hydrogels Prepared by Dual Ion Cross-Linking for Chronic Wound Healing".ACS Applied Materials and Interfaces 9.19(2017):16054-16062.
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