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Hydroxyapatite nanorod-assembled hierarchical microflowers: rapid synthesis via microwave hydrothermal transformation of CaHPO4and their application in protein/drug delivery
Yu, Ya-Dong1,2; Zhu, Ying-Jie1,2; Qi, Chao1; Wu, Jin1
2017
Source PublicationCeramics International
ISSN02728842
Volume43Issue:8Pages:6511-6518
AbstractHydroxyapatite (HAP) nanostructured materials have attracted much attention due to their excellent biocompatibility and promising applications in various biomedical fields. In this study, a facile method has been developed to synthesize HAP with flower-like hierarchical nanostructures. The flower-like CaHPO4precursor is firstly synthesized using triethyl phosphate (TEP) as the organic phosphorus source by the solvothermal method. The HAP hierarchical microflowers constructed with nanorods are then fabricated through rapid microwave hydrothermal transformation of the CaHPO4precursor in NaOH aqueous solution. The as-prepared HAP nanorod-assembled hierarchical microflowers are explored to study the protein/drug loading and release properties using hemoglobin (Hb) and ibuprofen (IBU) as a model protein and drug, respectively. The experimental results indicate that the as-prepared HAP nanorod-assembled hierarchical microflowers have relatively large specific surface area, high biocompatibility, high protein/drug loading capacity and pH-dependent sustained release properties. Thus, the as-prepared HAP nanorod-assembled hierarchical microflowers are promising for the applications in protein/drug delivery. © 2017 Elsevier Ltd and Techna Group S.r.l.
DOI10.1016/j.ceramint.2017.02.073
EI Accession Number20170903384936
EI KeywordsCalcium compounds
EI Classification Number461.9.1 Immunology - 761 Nanotechnology - 802.2 Chemical Reactions - 804.1 Organic Compounds - 804.2 Inorganic Compounds - 933 Solid State Physics
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Document Type期刊论文
Identifierhttp://ir.sic.ac.cn/handle/331005/25562
Collection中国科学院上海硅酸盐研究所
Affiliation1.State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai; 200050, China;
2.University of Chinese Academy of Sciences, Beijing; 100049, China
Recommended Citation
GB/T 7714
Yu, Ya-Dong,Zhu, Ying-Jie,Qi, Chao,et al. Hydroxyapatite nanorod-assembled hierarchical microflowers: rapid synthesis via microwave hydrothermal transformation of CaHPO4and their application in protein/drug delivery[J]. Ceramics International,2017,43(8):6511-6518.
APA Yu, Ya-Dong,Zhu, Ying-Jie,Qi, Chao,&Wu, Jin.(2017).Hydroxyapatite nanorod-assembled hierarchical microflowers: rapid synthesis via microwave hydrothermal transformation of CaHPO4and their application in protein/drug delivery.Ceramics International,43(8),6511-6518.
MLA Yu, Ya-Dong,et al."Hydroxyapatite nanorod-assembled hierarchical microflowers: rapid synthesis via microwave hydrothermal transformation of CaHPO4and their application in protein/drug delivery".Ceramics International 43.8(2017):6511-6518.
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